Protein complex info
Complex group nameISWI
Complex nameB-WICH
Genes in complexBAZ1B#66, DDX21#170, DEK#173, ERCC6#215, MYBBP1A#416, MYO1C#417, SF3B1#612, SIRT7#624, SMARCA5#630
Alternative namesWICH, WSTF-SNF2h, WSTF-ISWI
Proteins involvedBAZ1B/WSTF, DDX21, DEK, ERCC6, MYBBP1A, MYO1C, SF3B1, SIRT7, SMARCA5/SNF2H(ISWI-type ATPase)
Uniprot IDs of involved proteins
BAZ1B_HUMAN, DDX21_HUMAN, DEK_HUMAN, ERCC6_HUMAN, MBB1A_HUMAN, MYO1C_HUMAN, SF3B1_HUMAN, SIR7_HUMAN, SMCA5_HUMAN
PMID for reference on complex compositionPMID:16603771
Functionhistone phosphorylation complex, chromatin remodeling complex
PMID for reference on functionPMID:19092802, PMID:15753658
Target molecule typechromatin, histone
Specific targetH2AXY142
ProductH2AXY142ph
Target UniProt IDH2AX_HUMAN
PMID for reference on targets and productsPMID:19092802
CommentA chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress.
Status of entry#