Protein complex info
Complex group nameWMM
Complex nameWMM
Genes in complexMETTL3#390, METTL14#387, WTAP#770, ZC3H13#783, CBLL1#96, VIRMA#760
Alternative namesWTAP-METTL3-METTL14 N6-adenosine-methyltransferase complex, WTAP-METTL3-METTL14 methyltransferase complex, WMM methyltransferase complex
Proteins involvedMETTL3, METTL14, WTAP, ZC3H13, CBLL1, VIRMA
Uniprot IDs of involved proteins
MTA70_HUMAN, MET14_HUMAN, FL2D_HUMAN, ZC3HD_HUMAN, HAKAI_HUMAN, VIR_HUMAN
PMID for reference on complex compositionPMID:29348140
FunctionRNA methylation
PMID for reference on functionPMID:24316715
Target molecule typeRNA, DNA
Specific targetA of RNA, A of DNA
Productm6A
Target UniProt ID#
PMID for reference on targets and productsPMID:27281194
CommentRegulates processes dependent on RNA stability as m6A methylation leads to RNA degradation. Controls cell differentiation of embryonic and hematopoietic stem cells by destabilization of transcripts. Involved in response to DNA-damage. Mediates random X-inactivation by methylation of Xist-RNA. Marks primary microRNAs for processing. Promotes translation.
Status of entryNew