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EpiFactors is a database for epigenetic factors, corresponding genes and products.
Epigenetic factors are defined as:
Proteins that change the general structure of chromatin (chromatin remodeling), including
Specific subgroups of proteins may be annotated as such, e.g. the Polycomb group (PcG) proteins.
- Proteins that act upon post-translational modifications of histones (histone modification read, write and erase);
- Proteins that move, eject or restructure nucleosomes (ATP-dependent chromatin remodelers);
- Proteins that incorporate histone variants into the nucleosomes.
- Protein cofactors forming complexes with epigenetic factors, where complex formation is important for the activity (cofactor).
- Proteins acting as histones, histone variants or protamines (histone).
- Proteins assisting histone folding and assembly (histone chaperone).
- Proteins that act upon modifications of DNA or RNA in such a way that it affects gene expression, but not throught RNA processing (DNA or RNA modification).
- LncRNAs that are involved in epigenetic regulation by various mechanisms, including
- Recruitment or sequestration of a chromatin modifiers;
- Chromatin loop formation by recruitment of looping factors or R-loop formation;
- Regulation of alternative splicing by modification, recruitment or sequestration of splicing factors, chromatin remodeling or R-loop formation;
- miRNA sequestration (sponging).