| Complex group name | Complex name | Genes in complex | Alternative names | Proteins involved | Uniprot IDs of involved proteins | PMID for reference on complex composition | Function | PMID for reference on function | Target molecule type | Specific target | Product | Target UniProt ID | PMID for reference on targets and products | Comment | Status of entry |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ISWI |
ACF
(details) |
BAZ1A#65, SMARCA5#630 | ACF1-ISWI, ACF/WCRF | BAZ1A, SMARCA5/SNF2H(ISWI-type ATPase) | BAZ1A_HUMAN, SMCA5_HUMAN | 10655480, 25486562 | chromatin remodeling complex | 12434153, 14759371, 17099699 | chromatin | pericentromeric chromatin | # | # | 12434153 | Unfolding heterochromatin for replication. ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression. | # |
| APOB mRNA editosome |
APOB_mRNA_editosome
(details) |
APOBEC1#24, APOBEC3F#30, APOBEC3G#31, APOBEC3H#32, A1CF#1, AICDA#12, SYNCRIP#673 | Appoprotein B, APOBEC1, apolipoprotein B mRNA editing enzyme complex | A1CF, APOBEC3F, APOBEC3G, APOBEC3H, APOBEC1, AICDA, SYNCRIP | ABEC1_HUMAN, ABC3F_HUMAN, ABC3G_HUMAN, ABC3H_HUMAN, A1CF_HUMAN, AICDA_HUMAN, HNRPQ_HUMAN | 17121840 | mRNA editing complex | 11727199 | mRNA, DNA | dC, mC | dU, T | # | 11727199 | Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | # |
| HAT |
ATAC
(details) |
CSRP2BP#152, KAT2A#323, MBIP#377, DR1#190, CCDC101#105, TADA2A#675, TADA3#677, WDR5#764, YEATS2#772, ZZZ3#801 | ADA2A-containing complex | CSRP2BP, KAT2A, MBIP, DR1, CCDC101, TADA2A, TADA3, WDR5, YEATS2, ZZZ3 | CSR2B_HUMAN, KAT2A_HUMAN, MBIP1_HUMAN, NC2B_HUMAN, SGF29_HUMAN, TAD2A_HUMAN, TADA3_HUMAN, WDR5_HUMAN, YETS2_HUMAN, ZZZ3_HUMAN | 19103755 | histone acetylation complex | 19103755 | histone | H3, H4 | H3ac, H4ac | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN | 19103755 | A complex with histone acetyltransferase activity on histones H3 and H4. | # |
| ISWI |
B-WICH
(details) |
BAZ1B#66, DDX21#170, DEK#173, ERCC6#215, MYBBP1A#416, MYO1C#417, SF3B1#612, SIRT7#624, SMARCA5#630 | WICH, WSTF-SNF2h, WSTF-ISWI | BAZ1B/WSTF, DDX21, DEK, ERCC6, MYBBP1A, MYO1C, SF3B1, SIRT7, SMARCA5/SNF2H(ISWI-type ATPase) | BAZ1B_HUMAN, DDX21_HUMAN, DEK_HUMAN, ERCC6_HUMAN, MBB1A_HUMAN, MYO1C_HUMAN, SF3B1_HUMAN, SIR7_HUMAN, SMCA5_HUMAN | 16603771 | histone phosphorylation complex, chromatin remodeling complex | 19092802, 15753658 | chromatin, histone | H2AXY142 | H2AXY142ph | H2AX_HUMAN | 19092802 | A chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. | # |
| SWI/SNF |
BAF
(details) |
ACTL6A#4, ACTL6B#5, ACTB#3, ARID1A#33, ARID1B#34, DPF3#187?, SMARCA2#628, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCB1#633, (SMARCD1#636|SMARCD2#637|SMARCD3#638)+ | SWI/SNF-A | (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. | ACL6A_HUMAN, ACL6B_HUMAN, ACTB_HUMAN, ARI1A_HUMAN, ARI1B_HUMAN, DPF3_HUMAN?, SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SNF5_HUMAN, (SMRD1_HUMAN|SMRD2_HUMAN|SMRD3_HUMAN)+ | 10078207, 11078522 | chromatin remodeling complex | 10078207 | chromatin | # | # | # | # | In muscle cells, the BAF complex also contains DPF3, which specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). | # |
| PcG and PcG-like |
BCOR
(details) |
(BCOR#69|BCORL1#70), KDM2B#333, PCGF1#467, (RING1#568|RNF2#572), (RYBP#586|YAF2#771), SKP1#625, USP7#757 | PRC1.1, RING2-KDM2B | BCOR/BCORL1, RYBP/YAF2, PCGF1, RING1 or RNF2/RING2, KDM2B, USP7 and SKP1 | (BCOR_HUMAN|BCORL_HUMAN), KDM2B_HUMAN, PCGF1_HUMAN, (RING1_HUMAN|RING2_HUMAN), (RYBP_HUMAN|YAF2_HUMAN), SKP1_HUMAN, UBP7_HUMAN | 16943429, 22325352, 24217316 | Polycomb like complex | 16943429 | histone | H2AK119 | H2AK119ub1 | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN | # | A complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. | # |
| HDAC |
BHC
(details) |
GSE1#252?, GTF2I#254?, HDAC1#259, HDAC2#262, HMG20B#281, KDM1A#330, PHF21A#487, RCOR1#564, ZMYM2#788?, ZMYM3#789?, ZNF217#792? | BRAF-HDAC | HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I | GSE1_HUMAN?, GTF2I_HUMAN?, HDAC1_HUMAN, HDAC2_HUMAN, HM20B_HUMAN, KDM1A_HUMAN, PF21A_HUMAN, RCOR1_HUMAN, ZMYM2_HUMAN?, ZMYM3_HUMAN?, ZN217_HUMAN? | 12493763 | histone deacetylation complex | 12493763 | histone | # | # | # | # | A corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. | # |
| DUB |
BRCA1-A
(details) |
BABAM1#60, BARD1#64, BRCA1#73, BRCC3#75, BRE#84, FAM175A#231, UIMC1#744 | # | BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1 | BABA1_HUMAN, BARD1_HUMAN, BRCA1_HUMAN, BRCC3_HUMAN, BRE_HUMAN, F175A_HUMAN, UIMC1_HUMAN | 19261746, 19261748, 19261749 | histone deubiquitination complex | 19261746, 19261748, 19261749 | histone | H2AK63ub, H2AXK63ub | H2AK63, H2AXK63 | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN | 19261746, 19261748, 19261749 | A complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. | # |
| DUB |
BRCC
(details) |
BRCA1#73, BRCA2#74, BARD1#64, BRE#84, RAD51#538 | BRCA1/BRCA2 containing complex | BRCA1, BRCA2, BARD1, BRE and RAD51 | BRCA1_HUMAN, BRCA2_HUMAN, BARD1_HUMAN, BRE_HUMAN, RAD51_HUMAN | 14636569 | histone deubiquitination complex | 14636569 | histone | # | # | # | # | # | # |
| DUB |
BRISC
(details) |
BABAM1#60, BRCC3#75, BRE#84, FAM175B#232 | ABRO1 | FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1 | BABA1_HUMAN, BRCC3_HUMAN, BRE_HUMAN, F175B_HUMAN | 19214193 | histone deubiquitination complex | 19214193 | histone | H2Aub, H2AXub | H2A, H2AX | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN | 14636569 | # | # |
| CAF-1 |
CAF-1
(details) |
CHAF1A#129, CHAF1B#130, RBBP4#547 | # | RBBP4, CHAF1B and CHAF1A | CAF1A_HUMAN, CAF1B_HUMAN, RBBP4_HUMAN | 8858152 | chromatin assembly complex | 8858152 | histone | H3, H4 | # | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN | 8858152 | Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. | # |
| ISWI |
CERF
(details) |
CECR2#121, SMARCA1#627 | CECR2-containing-remodeling factor | CECR2, SMCA1 | CECR2_HUMAN, SMCA1_HUMAN | 25486562 | chromatin remodeling complex | 25486562 | chromatin | # | # | # | # | # | # |
| SWI/SNF |
CERF
(details) |
CECR2#121, SMARCA1#627 | CECR2-containing-remodeling factor complex | CECR2, SMARCA1 | CECR2_HUMAN, SMCA1_HUMAN | 15640247 | chromatin remodeling complex | 15640247 | chromatin | # | # | # | # | facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis. | # |
| MLL |
CHD8
(details) |
ASH2L#43, C17orf49#94?, CHD8#139, DPY30#189, E2F6#193?, HCFC1#257?, HCFC2#258?, (HSPA1A#294|HSPA1B#296)?, INO80C#309?, KANSL1#320?, KAT8#329?, KDM6A#345?, KMT2A#352, LAS1L#361?, MAX#369?, MCRS1#381?, MEN1#385?, MGA#392?, NCOA6#431?, PAGR1#458?, PAXIP1#464?, PELP1#474?, PHF20#485?, PRPF31#532?, RBBP5#548, RNF2#572?, RUVBL1#584?, RUVBL2#585?, SENP3#599?, TAF1#678?, TAF4#684?, TAF6#687?, TAF7#689?, TAF9#691?, TEX10#701?, WDR5#764 | MLL1/MLL, CHD8 | ASH2L, RBBP5, WDR5, DPY30, MLL and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin | ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, KMT2A_HUMAN, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, NCOA6_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?, RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN | 15960975, 22108599 | histone methylation complex, histone acetylation complex | 19556245 | histone | H3K4, H4K16 | H3K4me, H4K16ac | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN | 19556245 | A multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). | # |
| ISWI |
CHRAC
(details) |
CHRAC1#142, POLE3#494, BAZ1A#65, SMARCA5#630 | # | CHRAC1, POLE3, ACF1 and ISWI/SNF2H | CHRC1_HUMAN, DPOE3_HUMAN, BAZ1A_HUMAN, SMCA5_HUMAN | 10880450, 10801849, 25486562 | chromatin remodeling complex | 10880450 | chromatin | # | # | # | # | # | # |
| HMT |
COMPASS
(details) |
ASH2L#43, CXXC1#164, DPY30#189, HCFC1#257, RBBP5#548, (SETD1A#601|SETD1B#602), WDR5#764, WDR82#766 | SET1, Set1/Ash2 | SETD1A, WDR5, WDR82P1, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 | ASH2L_HUMAN, CXXC1_HUMAN, DPY30_HUMAN, HCFC1_HUMAN, RBBP5_HUMAN, (SET1A_HUMAN|SET1B_HUMAN), WDR5_HUMAN, WDR82_HUMAN | 16253997 | histone methylation complex | 12670868 | histone | H3K4 | H3K4me3 | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN | 12670868 | # | # |
| MLL |
COMPASS-like MLL1,2
(details) |
ASH2L#43, DPY30#189, HCFC1#257, KAT8#329, (KMT2A#352|KMT2D#355), MEN1#385, RBBP5#548, WDR5#764 | # | MLL1 or MLL2, MOF, Menin, ASH2L, DRY30, HCF1, RBBP5, WDR5 | ASH2L_HUMAN, DPY30_HUMAN, HCFC1_HUMAN, KAT8_HUMAN, (KMT2A_HUMAN|KMT2D_HUMAN), MEN1_HUMAN, RBBP5_HUMAN, WDR5_HUMAN | 22108599 | histone methylation complex, histone acetylation complex | 22108599 | histone | H4K16 | H4K16ac | H4_HUMAN | 22108599 | Hox-family gene regulator; tumor supressor activity. | # |
| MLL |
COMPASS-like MLL3,4
(details) |
ASH2L#43, DPY30#189, KDM6A#345, (KMT2B#353|KMT2C#354|KMT2D#355), NCOA6#431, PAGR1#458, PAXIP1#464, RBBP5#548, WDR5#764 | # | MLL3 or MLL4, UTX, NCOA6, PA1, PTIP, ASH2L, DRY30, RBBP5, WDR5 | ASH2L_HUMAN, DPY30_HUMAN, KDM6A_HUMAN, (KMT2B_HUMAN|KMT2C_HUMAN|KMT2D_HUMAN), NCOA6_HUMAN, PAGR1_HUMAN, PAXI1_HUMAN, RBBP5_HUMAN, WDR5_HUMAN | 22108599 | histone demethylation complex, histone acetylation complex | 22108599 | histone | # | # | # | # | # | # |
| CREST-BRG1 |
CREST-BRG1
(details) |
SS18L1#659, HDAC1#259, SMARCA4#629, SP1#647, RB1#546 | # | SMARCA4/BRG1/BAF190A, SS18L1/CREST, HDAC1, RB1 and SP1 | CREST_HUMAN, HDAC1_HUMAN, SMCA4_HUMAN, SP1_HUMAN, RB_HUMAN | Uniprot (by similarity) | chromatin remodeling complex | Uniprot (by similarity) | chromatin | # | # | # | # | A multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. | # |
| CRL4-DDB2 E3 ubiquitin ligase complex, CUL4A, CUL4B variants |
CRL4-DDB2 E3 ubiquitin ligase complex, CUL4A, CUL4B variants
(details) |
DDB2#168, DDB1#167, RBX1#562, CUL4A#161, CUL4B#162 | CUL4-DDB-ROC1 complex, CUL4-DDB-RBX1 complex | DDB2, DDB1, RBX1, CUL4B, CUL4A | DDB2_HUMAN, DDB1_HUMAN, RBX1_HUMAN, CUL4A_HUMAN, CUL4B_HUMAN | 21550341 | Histone ubiquitination complex | 21550341 | histone | # | # | # | 21550341 | Recognises UV-induced cyclobutane pyrimidine dimers in chromatin and ubiquitinates histones and other chromatin-associated proteins located around the DNA lesion. Promotes the removal of ubiquitinated histones from the nucleosome and subsequent DNA repair. | New |
| FACT |
FACT
(details) |
SSRP1#661, SUPT16H#664 | # | SSRP1 and SUPT16H | SSRP1_HUMAN, SP16H_HUMAN | 10421373 | chromatin remodeling complex | 16713563 | chromatin, histone | H2A, H2B | # | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H2B1A_HUMAN, H2B1B_HUMAN, H2B1C_HUMAN, H2B1D_HUMAN, H2B1H_HUMAN, H2B1J_HUMAN, H2B1K_HUMAN, H2B1L_HUMAN, H2B1M_HUMAN, H2B1N_HUMAN, H2B1O_HUMAN, H2B2C_HUMAN, H2B2D_HUMAN, H2B2E_HUMAN, H2B2F_HUMAN, H2B3B_HUMAN, H2BFM_HUMAN, H2BFS_HUMAN, H2BWT_HUMAN | 16713563 | A general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). | # |
| HAT |
HBO1
(details) |
MEAF6#383, (ING4#305|ING5#306), (JADE1#312|JADE2#313|JADE3#314)+, KAT7#328 | # | ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 | EAF6_HUMAN, (ING4_HUMAN|ING5_HUMAN), (JADE1_HUMAN|JADE2_HUMAN|JADE3_HUMAN)+, KAT7_HUMAN | 16387653 | histone acetylation complex | 10438470 | histone | H3, H4 | H3ac, H4ac | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN | 10438470 | Has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. | # |
| Ino80 |
Ino80
(details) |
ACTL6A#4, ACTR5#7, ACTR8#9, INO80#307, INO80B#308, INO80C#309, INO80D#310, MCRS1#381, NFRKB#436, RUVBL1#584, RUVBL2#585, TFPT#703, YY1#778, UCHL5#741 | INO80C | # | ACL6A_HUMAN, ARP5_HUMAN, ARP8_HUMAN, INO80_HUMAN, IN80B_HUMAN, IN80C_HUMAN, IN80D_HUMAN, MCRS1_HUMAN, NFRKB_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, TFPT_HUMAN, TYY1_HUMAN, UCHL5_HUMAN | 16230350 | chromatin remodeling complex | 16230350 | chromatin, histone | H2AS139ph | # | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN | 15607974 | The chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. | # |
| L3MBTL1 |
L3MBTL1
(details) |
CBX3#99, L3MBTL1#357, RB1#546 | # | L3MBTL1, HP1gamma, pRB | CBX3_HUMAN, LMBL1_HUMAN, RB_HUMAN | 17540172 | chromatin remodeling complex | 25482055 | chromatin, histone | H4K20me1, H4K20me2, H1bK26me1, H1bK26me2 | # | H14_HUMAN, H15_HUMAN, H4_HUMAN | 17540172 | # | # |
| CoREST |
LSD-CoREST
(details) |
CTBP1#153, GSE1#252, HDAC1#259, HDAC2#262, HMG20A#280, HMG20B#281, PHF21A#487, RCOR1#564, RCOR3#565, ZMYM2#788, ZNF217#792, ZNF516#793 | # | CoREST, HDAC1, HDAC2, BHC80, BRAF35, CtBP, Znf217, Znf516, Znf198, KIAA0182, KIAA1343, HMG20A | CTBP1_HUMAN, GSE1_HUMAN, HDAC1_HUMAN, HDAC2_HUMAN, HM20A_HUMAN, HM20B_HUMAN, PF21A_HUMAN, RCOR1_HUMAN, RCOR3_HUMAN, ZMYM2_HUMAN, ZN217_HUMAN, ZN516_HUMAN | 16140033, 16079794 | histone demethylation complex, histone acetylation complex | 25482055 | histone | H3K4me3 | # | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN | # | # | # |
| HMT |
MLL-HCF
(details) |
ASH2L#43, DPY30#189, HCFC1#257, HCFC2#258, KMT2A#352, MEN1#385, RBBP5#548, WDR5#764 | # | KMT2A/MLL1, MEN1, ASH2L, RBBP5, DPY30, WDR5, HCFC1 and HCFC2 | ASH2L_HUMAN, DPY30_HUMAN, HCFC1_HUMAN, HCFC2_HUMAN, KMT2A_HUMAN, MEN1_HUMAN, RBBP5_HUMAN, WDR5_HUMAN | 15199122 | histone methylation complex | 15199122 | histone | # | # | # | # | # | # |
| MLL |
MLL2/3
(details) |
ASH2L#43, C17orf49#94?, CHD8#139?, DPY30#189, E2F6#193?, HCFC1#257?, HCFC2#258?, (HSPA1A#294|HSPA1B#296)?, INO80C#309?, KANSL1#320?, KAT8#329?, KDM6A#345?, (KMT2B#353|KMT2C#354)+, LAS1L#361?, MAX#369?, MCRS1#381?, MEN1#385?, MGA#392?, NCOA6#431?, PAGR1#458?, PAXIP1#464?, PELP1#474?, PHF20#485?, PRPF31#532?, RBBP5#548, RNF2#572?, RUVBL1#584?, RUVBL2#585?, SENP3#599?, TAF1#678?, TAF4#684?, TAF6#687?, TAF7#689?, TAF9#691?, TEX10#701?, WDR5#764 | ASCOM | ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (MLL2/ALR and MLL3), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin | ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN?, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, (KMT2B_HUMAN|KMT2C_HUMAN)+, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, NCOA6_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?, RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN | 17500065 | histone methylation complex, histone acetylation complex | 17500065 | histone | H3K4 | H3K4me3 | # | 21330447 | # | # |
| MLL |
MLL4/WBP7
(details) |
ASH2L#43, C17orf49#94?, CHD8#139?, DPY30#189, E2F6#193?, HCFC1#257?, HCFC2#258?, (HSPA1A#294|HSPA1B#296)?, INO80C#309?, KANSL1#320?, KAT8#329?, KDM6A#345?, KMT2D#355, LAS1L#361?, MAX#369?, MCRS1#381?, MEN1#385?, MGA#392?, PAGR1#458?, PAXIP1#464?, PELP1#474?, PHF20#485?, PRPF31#532?, RBBP5#548, RNF2#572?, RUVBL1#584?, RUVBL2#585?, SENP3#599?, TAF1#678?, TAF4#684?, TAF6#687?, TAF7#689?, TAF9#691?, TEX10#701?, WDR5#764 | # | ASH2L, RBBP5, WDR5, DPY30, MLL4/WBP7, and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin | ASH2L_HUMAN, BAP18_HUMAN?, CHD8_HUMAN?, DPY30_HUMAN, E2F6_HUMAN?, HCFC1_HUMAN?, HCFC2_HUMAN?, HSP71_HUMAN?, IN80C_HUMAN?, KANL1_HUMAN?, KAT8_HUMAN?, KDM6A_HUMAN?, KMT2D_HUMAN, LAS1L_HUMAN?, MAX_HUMAN?, MCRS1_HUMAN?, MEN1_HUMAN?, MGAP_HUMAN?, PAGR1_HUMAN?, PAXI1_HUMAN?, PELP1_HUMAN?, PHF20_HUMAN?, PRP31_HUMAN?, RBBP5_HUMAN, RING2_HUMAN?, RUVB1_HUMAN?,RUVB2_HUMAN?, SENP3_HUMAN?, TAF1_HUMAN?, TAF4_HUMAN?, TAF6_HUMAN?, TAF7_HUMAN?, TAF9_HUMAN?, TEX10_HUMAN?, WDR5_HUMAN, | Uniprot | histone methylation complex, histone acetylation complex | Uniprot | histone | # | # | # | # | # | # |
| HAT |
MOZ/MORF
(details) |
(BRPF1#87|BRPF3#88|BRD1#76), MEAF6#383, ING5#306, KAT6A#326, KAT6B#327 | # | ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 | (BRPF1_HUMAN|BRPF3_HUMAN|BRD1_HUMAN), EAF6_HUMAN, ING5_HUMAN, KAT6A_HUMAN, KAT6B_HUMAN | 16387653, 18794358 | histone acetylation complex | 16387653 | histone | H3 | H3ac | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN | 16387653 | Has a histone H3 acetyltransferase activity. | # |
| HAT |
MSL histone acetyltransferase complex
(details) |
MSL1#407, MSL2#408, KAT8#329 | MSL1, MSL2, MSL3, KAT8 (hMOF) | MSL1_HUMAN, MSL2_HUMAN, M3SL1_HUMAN, KAT8_HUMAN | 16227571 | histone acetylation complex | 16227571, 17694080 | histone | H4 | H4K16Ac | H4_HUMAN | 16227571 | Responsible for genome-wide H4K16 acetylation. Affects chromatin organization and regulates transcription. Involved in regulation of cell cycle progression, DNA damage repair and apoptosis. | New | |
| HDAC |
MeCP1
(details) |
HDAC1#259, HDAC2#262, MBD2#372 | # | MBD2, HDAC1 and HDAC2 | HDAC1_HUMAN, HDAC2_HUMAN, MBD2_HUMAN | 10471499 | histone deacetylation complex, histone demethylation complex | 10471499 | histone | # | # | # | # | # | # |
| HMT |
Menin-associated_HMT
(details) |
ASH2L#43, DPY30#189, KMT2B#353, MEN1#385, RBBP5#548, WDR5#764 | # | KMT2B/MLL4, MEN1, ASH2L, RBBP5, DPY30 and WDR5 | ASH2L_HUMAN, DPY30_HUMAN, KMT2B_HUMAN, MEN1_HUMAN, RBBP5_HUMAN, WDR5_HUMAN | 17500065 | histone methylation complex | 17500065 | histone | H3K4 | H3K4me | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN | 16604156 | # | # |
| Mis18 |
Mis18
(details) |
MIS18A#395, OIP5#452, MIS18BP1#396 | # | MIS18A, OIP5, MIS18BP1 | MS18A_HUMAN, MS18B_HUMAN, M18BP_HUMAN | 22516971 | Chromatin remodeling | 22516971, 26942680 | histone | CENPA | # | # | 22516971 | Regulates CENPA recruitment to centromeres and thereby normal chromosome segregation during mitosis. Interacts with DNMT3A/3B and provides it`s centromeric localization regulating epigenetic states of centromeric chromatin. Provides access of CENPA-specific chaperone HJURP to centromeres. | New |
| HAT |
NSL
(details) |
HCFC1#257, KANSL1#320, KANSL2#321, KANSL3#322, KAT8#329, MCRS1#381, PHF20#485, OGT#451, WDR5#764 | # | MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 | HCFC1_HUMAN, KANL1_HUMAN, KANL2_HUMAN, KANL3_HUMAN, KAT8_HUMAN, MCRS1_HUMAN, PHF20_HUMAN, OGT1_HUMAN, WDR5_HUMAN | 20018852 | histone acetylation complex | 20018852 | histone | H4K16 | H4K16ac | H4_HUMAN | 20018852 | It is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. | # |
| ISWI |
NoRC
(details) |
BAZ2A#67, SMARCA5#630 | # | SMARCA5/SNF2H(ISWI-type ATPase), BAZ2A/TIP5 | BAZ2A_HUMAN, SMCA5_HUMAN | 11532953, 25486562 | chromatin remodeling complex | 11532953 | chromatin | # | # | # | # | A complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. | # |
| HAT |
NuA4
(details) |
ACTL6A#4, ACTB#3, BRD8#81, DMAP1#175, MEAF6#383, EP400#211, EPC1#212, ING3#304, KAT5#325, MORF4L1#400, MORF4L2#401, MRGBP#405, RUVBL1#584, RUVBL2#585, TRRAP#723, VPS72#761, YEATS4#773 | # | KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 | ACL6A_HUMAN, ACTB_HUMAN, BRD8_HUMAN, DMAP1_HUMAN, EAF6_HUMAN, EP400_HUMAN, EPC1_HUMAN, ING3_HUMAN, KAT5_HUMAN, MO4L1_HUMAN, MO4L2_HUMAN, MRGBP_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, TRRAP_HUMAN, VPS72_HUMAN, YETS4_HUMAN | 14966270, 16387653 | histone acetylation complex | 14966270 | histone | H4, H2A | H4ac, H2Aac | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H4_HUMAN | 14966270 | Is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. | # |
| HAT |
NuA4-related complex
(details) |
ACTL6A#4, ACTB#3, BRD8#81, DMAP1#175, EP400#211, EPC1#212, RUVBL1#584, RUVBL2#585, SRCAP#652, TRRAP#723, VPS72#761, YEATS4#773 | NuA4-related SCRAP-containing complex | EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41 | ACL6A_HUMAN, ACTB_HUMAN, BRD8_HUMAN, DMAP1_HUMAN, EP400_HUMAN, EPC1_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, SRCAP_HUMAN, TRRAP_HUMAN, VPS72_HUMAN, YETS4_HUMAN | Uniprot | histone acetylation complex | Uniprot | histone | # | # | # | # | # | # |
| HDAC |
NuRD
(details) |
CHD3#134, CHD4#135, HDAC1#259, HDAC2#262, KDM1A#330, MBD2#372, MBD3#373, MTA1#411, MTA2#412, MTA3#413, (GATAD2A#247|GATAD2B#248), RBBP4#547, RBBP7#549 | NRD, CHD3/CHD4 | HDAC1, HDAC2, RBBP4, RBBP7, MTA1, MTA2, MTA3, MBD2, MBD3, p66, CHD3 or CHD4, LSD1 | CHD3_HUMAN, CHD4_HUMAN, HDAC1_HUMAN, HDAC2_HUMAN, KDM1A_HUMAN, MBD2_HUMAN, MBD3_HUMAN, MTA1_HUMAN, MTA2_HUMAN, MTA3_HUMAN, (P66A_HUMAN|P66B_HUMAN), RBBP4_HUMAN, RBBP7_HUMAN | 19644445, 10589671, 17289569, 22108599 | histone deacetylation complex, histone methylation complex, chromatin remodeling complex | 10589671, 22108599 | histone | H3 | # | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN | 11850414 | The nucleosome remodeling and histone deacetylation complex. | # |
| ISWI |
NuRF
(details) |
BPTF#72, RBBP4#547, RBBP7#549, SMARCA1#627 | nucleosome-remodeling factor | SMARCA1; BPTF; RBBP4 and RBBP7 | BPTF_HUMAN, RBBP4_HUMAN, RBBP7_HUMAN, SMCA1_HUMAN | 20850016, 22108599 | chromatin remodeling complex | 20850016 | chromatin | # | # | # | # | Nucleosome-remodeling factor, a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Members: by similarity to mice. | # |
| SWI/SNF |
PBAF
(details) |
(ACTL6A#4|ACTL6B#5), ACTB#3, (ARID1A#33|ARID1B#34), ARID2#35, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCD1#636, SMARCD2#637, SMARCD3#638?, SMARCB1#633, PBRM1#466 | SWI/SNF-B | SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin | (ACL6A_HUMAN|ACL6B_HUMAN), ACTB_HUMAN, (ARI1A_HUMAN|ARI1B_HUMAN), ARID2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD2_HUMAN, SMRD3_HUMAN?, SNF5_HUMAN, PB1_HUMAN | 11078522, 11780067, 15985610 | chromatin remodeling complex | 11780067 | chromatin | # | # | # | # | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation. | # |
| HAT |
PCAF
(details) |
SUPT3H#665, TADA2A#675, TADA3#677, TAF5L#686, TAF6L#688, TAF10#679, TAF12#680, TRRAP#723, TAF9#691 | # | TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP | SUPT3_HUMAN, TAD2A_HUMAN, TADA3_HUMAN, TAF5L_HUMAN, TAF6L_HUMAN, TAF10_HUMAN, TAF12_HUMAN, TRRAP_HUMAN, TAF9_HUMAN, | 9674425 | histone acetylation complex | 8684459 | histone | H3K14, H3K18, H4K5, H4K8 | H3K14ac, H3K18ac, H4K5ac, H4K8ac | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN | 9880483 | # | # |
| PP |
PPP4C-PPP4R2-PPP4R3A
(details) |
PPP4C#498, PPP4R2#499, SMEK1#640 | PP4 | PPP4C, PPP4R2 and PPP4R3A | PP4C_HUMAN, PP4R2_HUMAN, P4R3A_HUMAN | 18758438 | dephosporylation complex | 18758438 | histone | H2AFXS139ph | H2AFXS139 | # | 18758438 | # | # |
| DUB |
PR-DUB
(details) |
ASXL1#44, BAP1#63 | # | BAP1 and ASXL1 | ASXL1_HUMAN, BAP1_HUMAN | 20436459 | histone deubiquitination complex | 20436459 | histone | H2AK119 | H2AK119ub1 | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN | 20436459 | A complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). | # |
| PcG and PcG-like |
PRC1
(details) |
(CBX2#98|CBX4#100|CBX6#102|CBX7#103|CBX8#104), (BMI1#71|PCGF1#467|PCGF2#468|PCGF3#469|PCGF5#470|PCGF6#471), PHC2#476, (RING1#568|RNF2#572), (SCMH1#595|SCML2#596) | PRC1.2, PRC1.4 | # | (CBX2_HUMAN|CBX4_HUMAN|CBX6_HUMAN|CBX7_HUMAN|CBX8_HUMAN), (BMI1_HUMAN|PCGF1_HUMAN|PCGF2_HUMAN|PCGF3_HUMAN|PCGF5_HUMAN|PCGF6_HUMAN), (PHC1_HUMAN, PHC2_HUMAN, PHC3_HUMAN), (RING1_HUMAN|RING2_HUMAN), (SCMH1_HUMAN| SCML2_HUMAN) | 12167701, 22325352, 24217316 | Polycomb group complex | 23418308 | histone | H2AK119 | H2AK119ub1 | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN | 23418308 | A complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. May modulate the levels of histone .H3K4Me3 by activating KDM5D histone demethylase. | # |
| PcG and PcG-like |
PRC2
(details) |
AEBP2#11, (JARID2#316|PHF1#478|MTF2#414|PHF19#483)?, EED#194, (EZH1#229|EZH2#230), SUZ12#672, (RBBP4#547|RBBP7#549) | # | EED, EZH1, SUZ12, RBBP4, RBBP7, JARID2 or PHF1 or PCL and AEBP2 | AEBP2_HUMAN, (JARD2_HUMAN|PHF1_HUMAN|MTF2_HUMAN|PHF19_HUMAN)?, EED_HUMAN, (EZH1_HUMAN|EZH2_HUMAN), SUZ12_HUMAN, (RBBP4_HUMAN|RBBP7_HUMAN) | 20075857, 23104054, 23273982, 22325352, 24217316 | Polycomb group complex | 15225548, 20075857 | histone | H3K9, H3K27 | H3K9me1, H3K9me2, H3K9me3, H3K27me1, H3K27me2, H3K27me3 | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN | 15225548, 20075857 | Methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, EZH1 is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. | # |
| HAT |
Piccolo_NuA4
(details) |
EPC1#212, ING3#304, KAT5#325 | minimal HAT complex | HTATTIP/TIP60, EPC1, and ING3 | EPC1_HUMAN, ING3_HUMAN, KAT5_HUMAN | 14966270 | histone acetylation complex | 14966270 | histone | H4, H2A | H4ac, H2Aac | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H4_HUMAN | 14966270 | Target is defined by similarity to yeast. | # |
| HAT |
Pol2 elongator
(details) |
IKBKAP#299, ELP2#204, ELP3#205, ELP4#206, ELP5#207, ELP6#208 | RNA polymerase II elongator complex | ELP1, ELP2, ELP3, ELP4, ELP5, ELP6 | ELP1_HUMAN, ELP2_HUMAN, ELP3_HUMAN, ELP4_HUMAN, ELP5_HUMAN, ELP6_HUMAN | 11714725, 11818576 | histone acetylation complex | 11714725 | histone | H3, H4 | H3ac, H4ac | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN, H4_HUMAN | 11714725 | A histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Original name "RNA polymerase II elongator complex". | # |
| PcG and PcG-like |
RING2-FBRS
(details) |
CSNK2A1#151, (FBRS#234|FBRSL1#235), (PCGF3#469|PCGF5#470), (RING1#568|RNF2#572), (RYBP#586|YAF2#771) | PRC1.3, PRC1.5 | RING1/RING2, FBRS/FBRSL1, RYBP/YAF2, PCGF3/PCGF5, CSNK2A1 | CSK21_HUMAN, (FBRS_HUMAN|FBSL_HUMAN), (PCGF3_HUMAN|PCGF5_HUMAN), (RING1_HUMAN|RING2_HUMAN), (RYBP_HUMAN|YAF2_HUMAN) | 22325352, 24217316 | Polycomb like complex | 22325352, 24217316 | histone | H2AK119 | H2AK119ub1 | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN | # | # | # |
| PcG and PcG-like |
RING2-L3MBTL2
(details) |
CBX3#99, E2F6#193, (HDAC1#259|HDAC2#262), L3MBTL2#358, MGA#392, PCGF6#471, (RING1#568|RNF2#572), (RYBP#586|YAF2#771), TFDP1#702, WDR5#764 | PRC1.6 | RING2, RYBP/YAF2, L3MBTL2, E2F6, PCGF6, CBX3, HDAC1/HDAC2, Dp-1, WDR5, MGA | CBX3_HUMAN, E2F6_HUMAN, (HDAC1_HUMAN|HDAC2_HUMAN), LMBL2_HUMAN, MGAP_HUMAN, PCGF6_HUMAN, (RING1_HUMAN|RING2_HUMAN), (RYBP_HUMAN|YAF2_HUMAN), TFDP1_HUMAN, WDR5_HUMAN | 22325352, 24217316 | Polycomb like complex | 22325352, 24217316 | histone | H2AK119 | H2AK119ub1 | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN | # | # | # |
| Exosome |
RNA exosome
(details) |
EXOSC1#216, EXOSC2#217, EXOSC3#218, EXOSC4#219, EXOSC5#220, EXOSC6#221, EXOSC7#222, EXOSC8#223, EXOSC9#224 | RNA exosome complex | EXOSC4, EXOSC9, EXOSC5, EXOSC8, EXOSC6, EXOSC7, EXOSC1, EXOSC2 and EXOSC3 | EXOS1_HUMAN, EXOS2_HUMAN, EXOS3_HUMAN, EXOS4_HUMAN, EXOS5_HUMAN, EXOS6_HUMAN, EXOS7_HUMAN, EXOS8_HUMAN, EXOS9_HUMAN | 17174896 | RNA exosome complex | 17174896 | RNA | # | # | # | # | # | # |
| ISWI |
RSF
(details) |
RSF1#582, SMARCA5#630 | ISWI-containing factor RSF | SMARCA5/SNF2H(ISWI-type ATPase), RSF1 | RSF1_HUMAN, SMCA5_HUMAN | 12972596, 25486562 | chromatin remodeling complex | 12972596 | chromatin | centromeric CENP-A chromatin | # | # | 19398759 | Assembly of regular nucleosome arrays. | # |
| HAT |
SAGA
(details) |
ATXN7L3#56, ATXN7#55, ENY2#209, KAT2A#323, SUPT3H#665, TAF10#679, TRRAP#723, USP22#751 | # | ATXN7, ATXN7L3, ENY2, KAT2A, SUPT3H, TAF10, TRRAP and USP22 | AT7L3_HUMAN, ATX7_HUMAN, ENY2_HUMAN, KAT2A_HUMAN, SUPT3_HUMAN, TAF10_HUMAN, TRRAP_HUMAN, UBP22_HUMAN | 10637607, 17337012 | histone acetylation complex, histone deubiquitination complex | 18206972 | histone | H2A, H2B, H2Aub, H2Bub | H2Aac, H2Bac, H2A, H2B | H2A1_HUMAN, H2A1A_HUMAN, H2A1B_HUMAN, H2A1C_HUMAN, H2A1D_HUMAN, H2A1H_HUMAN, H2A1J_HUMAN, H2A2A_HUMAN, H2A2B_HUMAN, H2A2C_HUMAN, H2A3_HUMAN, H2AB1_HUMAN, H2AB2_HUMAN, H2AJ_HUMAN, H2AV_HUMAN, H2AW_HUMAN, H2AX_HUMAN, H2AY_HUMAN, H2AZ_HUMAN, H2B1A_HUMAN, H2B1B_HUMAN, H2B1C_HUMAN, H2B1D_HUMAN, H2B1H_HUMAN, H2B1J_HUMAN, H2B1K_HUMAN, H2B1L_HUMAN, H2B1M_HUMAN, H2B1N_HUMAN, H2B1O_HUMAN, H2B2C_HUMAN, H2B2D_HUMAN, H2B2E_HUMAN, H2B2F_HUMAN, H2B3B_HUMAN, H2BFM_HUMAN, H2BFS_HUMAN, H2BWT_HUMAN | 18206972 | Histone acetylation (HAT) complex, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. | # |
| CoREST |
SCL
(details) |
KDM1A#330, RCOR1#564, SFMBT1#614 | # | SFMBT1, LSD1, CoREST | KDM1A_HUMAN, RCOR1_HUMAN, SMBT1_HUMAN | 23592795 | chromatin remodeling complex | 25482055 | histone | H4K20 | # | H4_HUMAN | 23592795 | # | # |
| SRCAP |
SRCAP
(details) |
ACTL6A#4, ACTR6#8, DMAP1#175, SRCAP#652, RUVBL1#584, RUVBL2#585, YEATS4#773, ZNHIT1#799 | # | SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1 | ACL6A_HUMAN, ARP6_HUMAN, DMAP1_HUMAN, SRCAP_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, YETS4_HUMAN, ZNHI1_HUMAN | 15647280 | chromatin remodeling complex | 15647280 | chromatin, histone | histone dimers containing H2B and H2A.Z | mononucleosomes reconstituted with recombinant H2A,H2B,H3,H4 | H2AZ_HUMAN, H2B1A_HUMAN, H2B1B_HUMAN, H2B1C_HUMAN, H2B1D_HUMAN, H2B1H_HUMAN, H2B1J_HUMAN, H2B1K_HUMAN, H2B1L_HUMAN, H2B1M_HUMAN, H2B1N_HUMAN, H2B1O_HUMAN, H2B2C_HUMAN, H2B2D_HUMAN, H2B2E_HUMAN, H2B2F_HUMAN, H2B3B_HUMAN, H2BFM_HUMAN, H2BFS_HUMAN, H2BWT_HUMAN | 16634648, 17617668 | Mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. SRCAP-containing complex supports ATP-dependent exchange of histone dimers containing H2B and H2A.Z into mononucleosomes reconstituted with recombinant H2A, H2B, H3, and H4. | # |
| HAT |
STAGA
(details) |
KAT2A#323, SUPT3H#665, SUPT7L#667, TADA1#674, TADA3#677, TAF5L#686, TAF6L#688, TAF9#691, TAF10#679, TAF12#680, TRRAP#723 | # | SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3, TAD1L, TAF10, TAF12, TRRAP and TAF9 | KAT2A_HUMAN, SUPT3_HUMAN, ST65G_HUMAN, TADA1_HUMAN, TADA3_HUMAN, TAF5L_HUMAN, TAF6L_HUMAN, TAF9_HUMAN, TAF10_HUMAN, TAF12_HUMAN, TRRAP_HUMAN | 11564863, 10637607, 17337012 | histone acetylation complex | 11564863 | histone | # | # | # | # | Complex with histone acetyltransferase activity, TAD1L is most likely a typo for TADA1L (=TADA1_HUMAN). | # |
| SWI/SNF |
SWI/SNF BRM-BRG1
(details) |
ACTL6A#4, ACTL6B#5, ARID1A#33, ARID1B#34, ACTB#3, BRD7#80, BRD9#82, DPF1#185, DPF3#187, SMARCA2#628, SMARCA4#629, SMARCC1#634, SMARCC2#635, SMARCD1#636, SMARCD2#637, SMARCD3#638, SMARCB1#633, PBRM1#466, PHF10#479, DPF2#186 | # | BRM, BRG1, actin, BAF45A, BAF45B, BAF45C, BAF45D, BAF47, BAF53A, BAF53B, BAF60A, BAF60B, BAF60C, BAF155, BAF170, BAF180, BAF200, BAF250A, BAF250B, BAP57, BRD7, BRD9 | ACL6A_HUMAN, ACL6B_HUMAN, ARI1A_HUMAN, ARI1B_HUMAN, ACTB_HUMAN, BRD7_HUMAN, BRD9_HUMAN, DPF1_HUMAN, DPF3_HUMAN, SMCA2_HUMAN, SMCA4_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD2_HUMAN, SMRD3_HUMAN, SNF5_HUMAN, PB1_HUMAN, PHF10_HUMAN, REQU_HUMAN | 22108599 | chromatin remodeling complex | 22108599 | chromatin | # | # | # | # | # | # |
| SWI/SNF |
SWI/SNF-like EPAFB
(details) |
ACTL6A#4, ACTB#3, ARID1B#34, MLLT1#397, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCD1#636, SMARCD2#637, SMARCB1#633 | EPAFB | SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, SMARCC1/BAF155, SMARCC2/BAF170, ARID1B/BAF250B, MLLT1/ENL and actin. | ACL6A_HUMAN, ACTB_HUMAN, ARI1B_HUMAN, ENL_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD2_HUMAN, SNF5_HUMAN | 12665591 | chromatin remodeling complex | 12665591 | chromatin | # | # | # | # | # | # |
| SWI/SNF |
SWI/SNF-like_EPAFa
(details) |
ACTL6A#4, ARID1B#34, MLLT1#397, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCD1#636, SMARCB1#633 | # | SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL | ACL6A_HUMAN, ARI1B_HUMAN, ENL_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SNF5_HUMAN | 12665591 | chromatin remodeling complex | 12665591 | chromatin | # | # | # | # | # | # |
| SWI/SNF |
SWI/SNF_Brg1(I)
(details) |
(ACTL6A#4|ACTL6B#5), ARID1A#33, HDAC2#262?, SIN3A#619, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, (SMARCD1#636|SMARCD2#637|SMARCD3#638)+, SMARCB1#633, RBBP4#547? | # | SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, and probably HDAC2 and RBAP4 | (ACL6A_HUMAN|ACL6B_HUMAN), ARI1A_HUMAN, HDAC2_HUMAN?, SIN3A_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, (SMRD1_HUMAN|SMRD2_HUMAN|SMRD3_HUMAN)+, SNF5_HUMAN, RBBP4_HUMAN? | Uniprot | chromatin remodeling complex | Uniprot | chromatin | # | # | # | # | # | # |
| SWI/SNF |
SWI/SNF_Brg1(II)
(details) |
(ACTL6A#4|ACTL6B#5), ARID1A#33, HDAC2#262?, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCB1#633, RBBP4#547? | # | SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A and probably HDAC2 and RBAP4 | (ACL6A_HUMAN|ACL6B_HUMAN), ARI1A_HUMAN, HDAC2_HUMAN?, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SNF5_HUMAN, RBBP4_HUMAN? | Uniprot | chromatin remodeling complex | Uniprot | chromatin | # | # | # | # | # | # |
| SWI/SNF |
SWI/SNF_Brm
(details) |
(ACTL6A#4|ACTL6B#5), ARID1A#33, HDAC1#259, HDAC2#262, SIN3A#619, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, (SMARCD1#636|SMARCD2#637|SMARCD3#638)+, SMARCB1#633, RBBP4#547 | # | SMARCA2/BRM/BAF190B, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, HDAC1, HDAC2, and RBAP4. | (ACL6A_HUMAN|ACL6B_HUMAN), ARI1A_HUMAN, HDAC1_HUMAN, HDAC2_HUMAN, SIN3A_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, (SMRD1_HUMAN|SMRD2_HUMAN|SMRD3_HUMAN)+, SNF5_HUMAN, RBBP4_HUMAN | Uniprot | chromatin remodeling complex | Uniprot | chromatin | # | # | # | # | # | # |
| SWR |
SWR
(details) |
ANP32E#21, BRD8#81, EP400#211, ING3#304, KAT5#325, RUVBL1#584, RUVBL2#585, TRRAP#723 | SWR1-like complex, SWR-C, SWR1-C | # | AN32E_HUMAN, BRD8_HUMAN, EP400_HUMAN, ING3_HUMAN, KAT5_HUMAN, RUVB1_HUMAN, RUVB2_HUMAN, TRRAP_HUMAN | 24463511 | chromatin remodeling complex | 24463511 | chromatin | # | # | # | # | # | # |
| HAT |
TFTC-HAT
(details) |
KAT2A#323, SUPT7L#667, TADA2B#676, TADA3#677, TAF2#682, TAF4#684, TAF5#685, TAF5L#686, TAF6#687, TAF6L#688, TAF9B#692, TAF10#679, TRRAP#723 | hTFTC, TFTC | KAT2A, SUPT3, TAD2B, TADA3, TADA3, TAF10, TAF2, TAF4, TAF5, TAF5L, TAF6, TAF6L, TAF9B, TRRAP | KAT2A_HUMAN, ST65G_HUMAN, TAD2B_HUMAN, TADA3_HUMAN, TAF2_HUMAN, TAF4_HUMAN, TAF5_HUMAN, TAF5L_HUMAN, TAF6_HUMAN, TAF6L_HUMAN, TAF9B_HUMAN, TAF10_HUMAN, TRRAP_HUMAN | 10373431 | histone acetylation complex | 10373431 | histone | H3 | H3ac | H31_HUMAN, H31T_HUMAN, H32_HUMAN, H33_HUMAN, H3C_HUMAN | 11406595 | TATA binding protein free TAFII-containing transcription complex. | # |
| SWI/SNF |
WINAC
(details) |
ACTL6A#4, ARID1A#33, BAZ1B#66, CHAF1B#130, SMARCA2#628, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCD1#636, SMARCB1#633, SUPT16H#664, TOP2B#714 | # | ACL6A, ARI1A, BAZ1B/WSTF, CAF1A, SMCA2, SMCA4, SMCE1, SMRC1, SMRC2, SMRD1, SNF5, SP16H, TOP2B | ACL6A_HUMAN, ARI1A_HUMAN, BAZ1B_HUMAN, CAF1B_HUMAN, SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SNF5_HUMAN, SP16H_HUMAN, TOP2B_HUMAN | 12837248 | chromatin remodeling complex | 12837248 | chromatin | # | # | # | # | A chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. "directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF)". | # |
| WMM |
WMM
(details) |
METTL3#390, METTL14#387, WTAP#770, ZC3H13#783, CBLL1#96, VIRMA#760 | WTAP-METTL3-METTL14 N6-adenosine-methyltransferase complex, WTAP-METTL3-METTL14 methyltransferase complex, WMM methyltransferase complex | METTL3, METTL14, WTAP, ZC3H13, CBLL1, VIRMA | MTA70_HUMAN, MET14_HUMAN, FL2D_HUMAN, ZC3HD_HUMAN, HAKAI_HUMAN, VIR_HUMAN | 29348140 | RNA methylation | 24316715 | RNA, DNA | A of RNA, A of DNA | m6A | # | 27281194 | Regulates processes dependent on RNA stability as m6A methylation leads to RNA degradation. Controls cell differentiation of embryonic and hematopoietic stem cells by destabilization of transcripts. Involved in response to DNA-damage. Mediates random X-inactivation by methylation of Xist-RNA. Marks primary microRNAs for processing. Promotes translation. | New |
| SWI/SNF |
bBAF
(details) |
ACTB#3, ARID1A#33, SMARCA2#628, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCD2#637, SMARCB1#633 | # | actin (ACTB), ARID1A/BAF250, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCC2/BAF170, SMARCD2/BAF60B and SMARCE1/BAF57 | ACTB_HUMAN, ARI1A_HUMAN, SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD2_HUMAN, SNF5_HUMAN | Uniprot (by similarity) | chromatin remodeling complex | Uniprot (by similarity) | chromatin | # | # | # | # | # | # |
| HDAC |
core HDAC
(details) |
HDAC1#259, HDAC2#262, RBBP4#547, RBBP7#549 | # | HDAC1, HDAC2, RBBP4 and RBBP7 | HDAC1_HUMAN, HDAC2_HUMAN, RBBP4_HUMAN, RBBP7_HUMAN | 12711221, 22108599 | histone deacetylation complex | 12711221 | histone | # | # | # | # | Original name "core histone deacetylase complex". | # |
| HMT |
eNoSc
(details) |
RRP8#581, SUV39H1#668, SIRT1#621 | # | SIRT1, SUV39H1 and RRP8 | RRP8_HUMAN, SUV91_HUMAN, SIR1_HUMAN | 18485871 | histone methylation complex, histone deacetylation complex | 18485871 | histone, DNA | H3K9, H3K9ac | H3K9me | # | # | # | # |
| HDAC |
mSin3A
(details) |
ARID4A#36, ARID4B#37, BRMS1#85, BRMS1L#86, HDAC1#259, HDAC2#262, SAP18#589, SAP30#591, SUDS3#663, SIN3A#619, SIN3B#620, RBBP4#547, RBBP7#549 | Sin3, Sin3A | SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2, BRMS1L, SUDS3, ARID4A, SAP18, SAP180 | ARI4A_HUMAN, ARI4B_HUMAN, BRMS1_HUMAN, BRM1L_HUMAN, HDAC1_HUMAN, HDAC2_HUMAN, SAP18_HUMAN, SAP30_HUMAN, SDS3_HUMAN, SIN3A_HUMAN, SIN3B_HUMAN, RBBP4_HUMAN, RBBP7_HUMAN | 12724404, 15451426 | histone deacetylation complex | 12670868 | histone | # | # | # | # | # | # |
| HDAC |
mSin3A-like complex
(details) |
HDAC1#259, HDAC2#262, ING2#303, SAP30#591, SIN3A#619, RBBP4#547, RBBP7#549 | Sin3/HDAC1 corepressor complex | SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2 | HDAC1_HUMAN, HDAC2_HUMAN, ING2_HUMAN, SAP30_HUMAN, SIN3A_HUMAN, RBBP4_HUMAN, RBBP7_HUMAN | 11784859, 16387653 | histone deacetylation complex | 16387653 | histone | # | # | # | # | # | # |
| HMT |
methylosome
(details) |
PRMT5#527, CLNS1A#147, WDR77#765 | 20S PRMT5-containing methyltransferase complex | PRMT5, CLNS1A and WDR77 | ANM5_HUMAN, ICLN_HUMAN, MEP50_HUMAN | 11756452 | histone methylation complex | 11756452 | histone | H2AR | H2ARme2 | # | # | # | # |
| SWI/SNF |
nBAF
(details) |
ACTL6B#5, ACTB#3, (ARID1A#33|ARID1B#34), DPF1#185, DPF3#187, SMARCA2#628, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCD1#636, SMARCD3#638, SMARCB1#633 | neuron-specific chromatin remodeling complex | ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin | ACL6B_HUMAN, ACTB_HUMAN, (ARI1A_HUMAN|ARI1B_HUMAN), DPF1_HUMAN, DPF3_HUMAN, SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD3_HUMAN, SNF5_HUMAN | 10078207, 11078522, 18765789, by similarity | chromatin remodeling complex | 11078522 | chromatin | # | # | # | # | The neuron-specific chromatin remodeling complex. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. | # |
| SWI/SNF |
npBAF
(details) |
ACTL6A#4, ACTB#3, (ARID1A#33|ARID1B#34), SMARCA2#628, SMARCA4#629, SMARCE1#639, SMARCC1#634, SMARCC2#635, SMARCD1#636, SMARCD3#638, SMARCB1#633, PHF10#479 | neural progenitors-specific chromatin remodeling complex, BAF53 | ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin | ACL6A_HUMAN, ACTB_HUMAN, (ARI1A_HUMAN|ARI1B_HUMAN), SMCA2_HUMAN, SMCA4_HUMAN, SMCE1_HUMAN, SMRC1_HUMAN, SMRC2_HUMAN, SMRD1_HUMAN, SMRD3_HUMAN, SNF5_HUMAN, PHF10_HUMAN | 10078207, 11078522, 18765789, by similarity | chromatin remodeling complex | 11078522 | chromatin | # | # | # | # | Neural progenitors-specific chromatin remodeling complex. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. | # |