| Complex group name | CRL4-DDB2 E3 ubiquitin ligase complex, CUL4A, CUL4B variants |
| Complex name | CRL4-DDB2 E3 ubiquitin ligase complex, CUL4A, CUL4B variants |
| Genes in complex | DDB2#168, DDB1#167, RBX1#562, CUL4A#161, CUL4B#162 |
| Alternative names | CUL4-DDB-ROC1 complex, CUL4-DDB-RBX1 complex |
| Proteins involved | DDB2, DDB1, RBX1, CUL4B, CUL4A |
| Uniprot IDs of involved proteins | DDB2_HUMAN, DDB1_HUMAN, RBX1_HUMAN, CUL4A_HUMAN, CUL4B_HUMAN |
| PMID for reference on complex composition | PMID:21550341 |
| Function | Histone ubiquitination complex |
| PMID for reference on function | PMID:21550341 |
| Target molecule type | histone |
| Specific target | # |
| Product | # |
| Target UniProt ID | # |
| PMID for reference on targets and products | PMID:21550341 |
| Comment | Recognises UV-induced cyclobutane pyrimidine dimers in chromatin and ubiquitinates histones and other chromatin-associated proteins located around the DNA lesion. Promotes the removal of ubiquitinated histones from the nucleosome and subsequent DNA repair. |
| Status of entry | New |