| HGNC approved symbol | CHAF1B |
| HGNC ID | HGNC:1911 |
| HGNC approved name | chromatin assembly factor 1, subunit B (p60) |
| Entrez gene ID | GeneID:8208 (SSTAR profile) |
| UniProt AC (human) | Q13112 |
| UniProt ID (human) | CAF1B_HUMAN |
| Pfam domains | WD40 PF00400 (60-94, 121-157, 162-199, 345-372) CAF-1_p60_C PF15512 (384-540) |
| MGI symbol | Chaf1b |
| MGI ID | MGI:1314881 |
| UniProt AC (mouse) | Q9D0N7 |
| UniProt ID (mouse) | CAF1B_MOUSE |
| HGNC gene family tag | WDR |
| HGNC gene family description | WD repeat domain containing |
| Function | Chromatin remodeling |
| Modification | # |
| PMID for information on function | PMID:7600578 |
| Protein complex | WINAC, CAF-1 |
| Target molecule | histone |
| Target entity | H3, H4 |
| Product | # |
| PMID for information on target | PMID:7600578 |
| Comment | p150 and p60==CHAF1B directly interact and are both required for DNA replication-dependent assembly of nucleosomes. Deletion of the p60-binding domain from the p150 protein prevents chromatin assembly. p150 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in human cell extracts, suggesting that such complexes are intermediates between histone synthesis and assembly onto replicating DNA. |
| Status of entry | # |
| Expression range: | 0.0 to 53.41 |
| Mean expression: | 5.9 ± 5.76 |
| Median expression: | 4.14 |