| HGNC approved symbol | RUVBL1 |
| HGNC ID | HGNC:10474 |
| HGNC approved name | RuvB-like AAA ATPase 1 |
| Entrez gene ID | GeneID:8607 (SSTAR profile) |
| UniProt AC (human) | Q9Y265 |
| UniProt ID (human) | RUVB1_HUMAN |
| Pfam domains | TIP49 PF06068 (14-368) TIP49_C PF17856 (374-439) |
| MGI symbol | Ruvbl1 |
| MGI ID | MGI:1928760 |
| UniProt AC (mouse) | P60122 |
| UniProt ID (mouse) | RUVB1_MOUSE |
| HGNC gene family tag | INO80, AATP |
| HGNC gene family description | INO80 complex subunits, ATPases / AAA-type |
| Function | Chromatin remodeling, Histone modification write |
| Modification | Histone phosphorylation |
| PMID for information on function | PMID:14695187 |
| Protein complex | Ino80, SWR, NuA4, NuA4-related complex, CHD8, MLL2/3, MLL4/WBP7, SRCAP |
| Target molecule | chromatin |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:14695187 |
| Comment | The ability of TIP49=RUVBL1 to inhibit ITF-2 gene expression has been linked to decreased acetylation of histones in the vicinity of the TCF-binding sites in the ITF-2 promoter region. It has been suggested that TIP49 is an important cofactor in beta-catenin/TCF gene regulation in normal and neoplastic cells, likely functioning in chromatin remodeling. |
| Status of entry | # |
| Expression range: | 0.0 to 210.57 |
| Mean expression: | 52.34 ± 33.79 |
| Median expression: | 46.53 |