HGNC approved symbol | SUV39H1 |
HGNC ID | HGNC:11479 |
HGNC approved name | suppressor of variegation 3-9 homolog 1 (Drosophila) |
Entrez gene ID | GeneID:6839 (SSTAR profile) |
UniProt AC (human) | O43463 |
UniProt ID (human) | SUV91_HUMAN |
Pfam domains | Chromo PF00385 (43-91) Pre-SET PF05033 (141-235) SET PF00856 (255-366) |
MGI symbol | Suv39h1 |
MGI ID | MGI:1099440 |
UniProt AC (mouse) | O54864 |
UniProt ID (mouse) | SUV91_MOUSE |
HGNC gene family tag | KMT |
HGNC gene family description | Chromatin-modifying enzymes / K-methyltransferases |
Function | Histone modification write, Histone modification write |
Modification | Histone methylation, Histone phosphorylation |
PMID for information on function | PMID:10949293 |
Protein complex | eNoSc |
Target molecule | histone |
Target entity | H3S10, H3K9me1, H4 |
Product | H3K9me3 |
PMID for information on target | PMID:10949293 |
Comment | In vivo, deregulated SUV39H1 or disrupted Suv39h activity modulate H3 serine 10 phosphorylation in native chromatin and induce aberrant mitotic divisions. |
Status of entry | # |
Expression range: | 0.0 to 35.3 |
Mean expression: | 5.94 ± 5.3 |
Median expression: | 4.32 |