| HGNC approved symbol | AICDA |
| HGNC ID | HGNC:13203 |
| HGNC approved name | activation-induced cytidine deaminase |
| Entrez gene ID | GeneID:57379
(SSTAR profile) |
| UniProt AC (human) | Q9GZX7 |
| UniProt ID (human) | AICDA_HUMAN |
| Pfam domains | APOBEC_N PF08210 (9-177) |
| MGI symbol | Aicda |
| MGI ID | MGI:1342279 |
| UniProt AC (mouse) | Q9WVE0 |
| UniProt ID (mouse) | AICDA_MOUSE |
| HGNC gene family tag | APOBEC |
| HGNC gene family description | Apolipoprotein B mRNA editing enzymes |
| Function | DNA modification |
| Modification | DNA demethylation |
| PMID for information on function | PMID:21496894 |
| Protein complex | APOB_mRNA_editosome |
| Target molecule | DNA |
| Target entity | ssDNA, hmC |
| Product | hmU |
| PMID for information on target | PMID:21496894 |
| Comment | AICDA or AID is required for OCT4 and NANOG promoter demethylation, 5mCs are first oxidized to 5hmCs by TET proteins. 5hmCs are then deaminated by AID/APOBEC deaminases into 5hmU. Finally, 5hmU can be excised by 5hmU glycosylases and repaired by the BER pathway with unmethylated cytosines |
| Status of entry | # |