| HGNC approved symbol | APBB1 |
| HGNC ID | HGNC:581 |
| HGNC approved name | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) |
| Entrez gene ID | GeneID:322 (SSTAR profile) |
| UniProt AC (human) | O00213 |
| UniProt ID (human) | APBB1_HUMAN |
| Pfam domains | WW PF00397 (256-283) PID PF00640 (370-507, 542-664) |
| MGI symbol | Apbb1 |
| MGI ID | MGI:107765 |
| UniProt AC (mouse) | Q9QXJ1 |
| UniProt ID (mouse) | APBB1_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification |
| Modification | # |
| PMID for information on function | PMID:21403922 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2AX |
| Product | # |
| PMID for information on target | # |
| Comment | Chromatin acetylation, β-amyloid precursor protein and its binding partner FE65 in DNA double strand break repair. UniProt: May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). |
| Status of entry | # |
| Expression range: | 0.0 to 273.47 |
| Mean expression: | 18.56 ± 30.03 |
| Median expression: | 11.35 |