| HGNC approved symbol | APOBEC1 |
| HGNC ID | HGNC:604 |
| HGNC approved name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 |
| Entrez gene ID | GeneID:339
(SSTAR profile) |
| UniProt AC (human) | P41238 |
| UniProt ID (human) | ABEC1_HUMAN |
| Pfam domains | APOBEC4_like PF18774 (27-158) |
| MGI symbol | Apobec1 |
| MGI ID | MGI:103298 |
| UniProt AC (mouse) | P51908 |
| UniProt ID (mouse) | ABEC1_MOUSE |
| HGNC gene family tag | APOBEC |
| HGNC gene family description | Apolipoprotein B mRNA editing enzymes |
| Function | DNA modification, RNA modification |
| Modification | DNA demethylation, mRNA editing |
| PMID for information on function | PMID:22001110 |
| Protein complex | APOB_mRNA_editosome |
| Target molecule | DNA, RNA |
| Target entity | ssDNA, mRNA, mC |
| Product | U |
| PMID for information on target | PMID:22001110 |
| Comment | Fig. A2 in the reference (APOBEC1 or A1 has no known mammalian DNA substrate but it has DNA deaminase activity sufficient to induce reversion mutations when overexpressed in E. coli. In addition, A1 expressed in neurons may have a protective function against HSV (Herpers simplex virus) that involves ssDNA deamination of the viral genome). |
| Status of entry | # |