Gene info
| HGNC approved symbol | ARNTL |
| HGNC ID | HGNC:701 |
| HGNC approved name | aryl hydrocarbon receptor nuclear translocator-like |
| Entrez gene ID | GeneID:406 (SSTAR profile) |
| UniProt AC (human) | O00327 |
| UniProt ID (human) | BMAL1_HUMAN |
| Pfam domains | HLH PF00010 (74-126) PAS PF00989 (149-254) PAS_11 PF14598 (339-442) |
| MGI symbol | Arntl |
| MGI ID | MGI:1096381 |
| UniProt AC (mouse) | Q9WTL8 |
| UniProt ID (mouse) | BMAL1_MOUSE |
| HGNC gene family tag | bHLH |
| HGNC gene family description | Basic helix-loop-helix proteins |
| Function | Histone modification write cofactor, TF |
| Modification | TF activator |
| PMID for information on function | PMID:14645221, PMID:24395244 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | # |
| HOCOMOCO TFBS model | |
| Product | # |
| PMID for information on target | PMID:14645221, PMID:24395244 |
| Comment | The coincidence of a rhythm in histone H3 and histone H4 acetylation on the proximal E-box of hPer1 with transcriptional activation of per1 and per2 is consistent with the heterodimeric complexes of CLOCK, NPAS2 and BMAL1 = ARNTL recruiting a histone acetyltransferase (HAT)-containing transcriptional co-activation complex to achieve maximal target gene activation; CLOCK:BMAL1 functions like pioneer transcription factors and regulates the DNA accessibility of other transcription factors. |
| Status of entry | # |
Expression statistics
| Expression range: | 0.0 to 206.9 |
| Mean expression: | 14.43 ± 18.13 |
| Median expression: | 8.36 |