HGNC approved symbol | ATR |
HGNC ID | HGNC:882 |
HGNC approved name | ATR serine/threonine kinase |
Entrez gene ID | GeneID:545 (SSTAR profile) |
UniProt AC (human) | Q13535 |
UniProt ID (human) | ATR_HUMAN |
Pfam domains | UME PF08064 (1125-1221) FAT PF02259 (1770-2090) PI3_PI4_kinase PF00454 (2322-2567) FATC PF02260 (2613-2644) |
MGI symbol | Atr |
MGI ID | MGI:108028 |
UniProt AC (mouse) | Q9JKK8 |
UniProt ID (mouse) | ATR_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone phosphorylation |
PMID for information on function | PMID:11673449 |
Protein complex | # |
Target molecule | histone |
Target entity | H2AX |
Product | # |
PMID for information on target | PMID:11673449 |
Comment | While H2AX phosphorylation requires ATR, this phosphorylation event is independent of Hus1. Thus, the phosphorylated H2AX may function upstream of Hus1 in the transduction of DNA damage. |
Status of entry | # |
Expression range: | 0.0 to 67.31 |
Mean expression: | 16.5 ± 9.12 |
Median expression: | 14.99 |