| HGNC approved symbol | ATRX |
| HGNC ID | HGNC:886 |
| HGNC approved name | alpha thalassemia/mental retardation syndrome X-linked |
| Entrez gene ID | GeneID:546 (SSTAR profile) |
| UniProt AC (human) | P46100 |
| UniProt ID (human) | ATRX_HUMAN |
| Pfam domains | ADD_ATRX PF17981 (162-213) SNF2-rel_dom PF00176 (1563-1888) Helicase_C PF00271 (2022-2155) |
| MGI symbol | Atrx |
| MGI ID | MGI:103067 |
| UniProt AC (mouse) | Q61687 |
| UniProt ID (mouse) | ATRX_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Chromatin remodeling |
| Modification | # |
| PMID for information on function | PMID:9499421 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K9me2, H3K9me3, H3K4 |
| Product | # |
| PMID for information on target | PMID:9499421, PMID:21666677 |
| Comment | The characteristics of the helicase domains make the XNP protein a new member of the SNF2/SWI DNA helicase family. XNP could regulate gene expression by direct interaction with heterochromatin-associated proteins.A yeast two-hybrid analysis using XNP and several human heterochromatin-associated proteins showed a specific interaction between the XNP and the EZH2 proteins. |
| Status of entry | # |
| Expression range: | 0.0 to 167.01 |
| Mean expression: | 32.87 ± 21.54 |
| Median expression: | 28.24 |