| HGNC approved symbol | ATXN7L3 |
| HGNC ID | HGNC:25416 |
| HGNC approved name | ataxin 7-like 3 |
| Entrez gene ID | GeneID:56970 (SSTAR profile) |
| UniProt AC (human) | Q14CW9 |
| UniProt ID (human) | AT7L3_HUMAN |
| Pfam domains | Sgf11 PF08209 (81-112) SCA7 PF08313 (207-237) |
| MGI symbol | Atxn7l3 |
| MGI ID | MGI:3036270 |
| UniProt AC (mouse) | A2AWT3 |
| UniProt ID (mouse) | AT7L3_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification erase cofactor |
| Modification | Histone deubiquitination |
| PMID for information on function | PMID:18206972 |
| Protein complex | SAGA |
| Target molecule | histone |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:18206972 |
| Comment | ATXN7L3, USP22, and ENY2 are the human orthologs of yeast Sgf11, Ubp8, and Sus1, respectively, and they are integral components of TFTC/STAGA complex. These three proteins together form a module of the TFTC/STAGA complex, which specifically removes the ubiquitin moiety from monoubiquitinated histones H2A and H2B. |
| Status of entry | # |
| Expression range: | 0.0 to 50.41 |
| Mean expression: | 5.2 ± 3.37 |
| Median expression: | 4.45 |