| HGNC approved symbol | BRCC3 |
| HGNC ID | HGNC:24185 |
| HGNC approved name | BRCA1/BRCA2-containing complex, subunit 3 |
| Entrez gene ID | GeneID:79184 (SSTAR profile) |
| UniProt AC (human) | P46736 |
| UniProt ID (human) | BRCC3_HUMAN |
| Pfam domains | JAB PF01398 (8-147) BRCC36_C PF18110 (226-308) |
| MGI symbol | Brcc3 |
| MGI ID | MGI:2389572 |
| UniProt AC (mouse) | P46737 |
| UniProt ID (mouse) | BRCC3_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification erase |
| Modification | Histone deubiquitination |
| PMID for information on function | PMID:19202061 |
| Protein complex | BRISC, BRCA1-A |
| Target molecule | histone |
| Target entity | H2AK63, H2AXK63 |
| Product | H2A, H2AX |
| PMID for information on target | PMID:19202061 |
| Comment | Involved in DNA damage response and reverses RNF8 ubiquitination activity. Rap80-BRCC36 DUB Activity and γH2AX hydrolysis Ubiquitination. Rap80 is required for BRCA1 and BRCC36 localization to DSBs. |
| Status of entry | # |
| Expression range: | 0.0 to 68.31 |
| Mean expression: | 10.19 ± 6.53 |
| Median expression: | 9.14 |