| HGNC approved symbol | CARM1 |
| HGNC ID | HGNC:23393 |
| HGNC approved name | coactivator-associated arginine methyltransferase 1 |
| Entrez gene ID | GeneID:10498 (SSTAR profile) |
| UniProt AC (human) | Q86X55 |
| UniProt ID (human) | CARM1_HUMAN |
| Pfam domains | CARM1 PF11531 (27-139) PrmA PF06325 (184-257) domain PF22528 (291-453) |
| MGI symbol | Carm1 |
| MGI ID | MGI:1913208 |
| UniProt AC (mouse) | Q9WVG6 |
| UniProt ID (mouse) | CARM1_MOUSE |
| HGNC gene family tag | PRMT |
| HGNC gene family description | Protein arginine methyltransferases |
| Function | Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:12237300 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3R17 |
| Product | H3R17me, H3R17me2a |
| PMID for information on target | PMID:16497732, PMID:19405910 |
| Comment | Methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. CARM1-directed arginine methylation of histone H3 in the promoters of steroid hormone-responsive genes is induced by steroid hormone treatment of cells. |
| Status of entry | # |
| Expression range: | 0.0 to 153.79 |
| Mean expression: | 23.99 ± 13.85 |
| Median expression: | 21.89 |