HGNC approved symbol | CBX8 |
HGNC ID | HGNC:15962 |
HGNC approved name | chromobox homolog 8 |
Entrez gene ID | GeneID:57332 (SSTAR profile) |
UniProt AC (human) | Q9HC52 |
UniProt ID (human) | CBX8_HUMAN |
Pfam domains | Chromo PF00385 (11-60) CBX7_C PF17218 (348-381) |
MGI symbol | Cbx8 |
MGI ID | MGI:1353589 |
UniProt AC (mouse) | Q9QXV1 |
UniProt ID (mouse) | CBX8_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification read |
Modification | # |
PMID for information on function | PMID:21047797 |
Protein complex | PRC1 |
Target molecule | histone |
Target entity | H3K9me3, H3K27me3 |
Product | # |
PMID for information on target | PMID:21047797 |
Comment | Cbx6 and Cbx8 have functional aromatic cages and hydrophobic fingers very similar to those of Cbx2, -4, and -7, but the former bind to H3K9me3 and H3K27me3 peptides with much lower affinity. |
Status of entry | # |
Expression range: | 0.0 to 26.42 |
Mean expression: | 4.99 ± 3.85 |
Median expression: | 3.95 |