HGNC approved symbol | CHEK1 |
HGNC ID | HGNC:1925 |
HGNC approved name | checkpoint kinase 1 |
Entrez gene ID | GeneID:1111 (SSTAR profile) |
UniProt AC (human) | O14757 |
UniProt ID (human) | CHK1_HUMAN |
Pfam domains | Pkinase PF00069 (10-264) |
MGI symbol | Chek1 |
MGI ID | MGI:1202065 |
UniProt AC (mouse) | O35280 |
UniProt ID (mouse) | CHK1_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone phosphorylation |
PMID for information on function | # |
Protein complex | # |
Target molecule | histone |
Target entity | H3.1 |
Product | H3.1ph |
PMID for information on target | # |
Comment | UniProt: May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes. |
Status of entry | # |