HGNC approved symbol | CHUK |
HGNC ID | HGNC:1974 |
HGNC approved name | conserved helix-loop-helix ubiquitous kinase |
Entrez gene ID | GeneID:1147 (SSTAR profile) |
UniProt AC (human) | O15111 |
UniProt ID (human) | IKKA_HUMAN |
Pfam domains | Pkinase PF00069 (16-290) IKBKB_SDD PF18397 (387-658) IKKbetaNEMObind PF12179 (708-744) |
MGI symbol | Chuk |
MGI ID | MGI:99484 |
UniProt AC (mouse) | Q60680 |
UniProt ID (mouse) | IKKA_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone phosphorylation |
PMID for information on function | PMID:17434128 |
Protein complex | # |
Target molecule | histone |
Target entity | H3 |
Product | # |
PMID for information on target | PMID:17434128 |
Comment | In the nucleus, IKKα=CHUK is recruited to the promoter region of the NF-κB-regulated genes by interacting with CBP, and contributes to NF-κB-mediated gene expressions through phosphorylation of histone H3. |
Status of entry | # |
Expression range: | 0.0 to 92.41 |
Mean expression: | 19.55 ± 9.9 |
Median expression: | 18.6 |