HGNC approved symbol | CUL3 |
HGNC ID | HGNC:2553 |
HGNC approved name | cullin 3 |
Entrez gene ID | GeneID:8452 (SSTAR profile) |
UniProt AC (human) | Q13618 |
UniProt ID (human) | CUL3_HUMAN |
Pfam domains | Cullin PF00888 (34-665) Cullin_Nedd8 PF10557 (698-760) |
MGI symbol | Cul3 |
MGI ID | MGI:1347360 |
UniProt AC (mouse) | Q9JLV5 |
UniProt ID (mouse) | CUL3_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone ubiquitination |
PMID for information on function | PMID:15897469 |
Protein complex | # |
Target molecule | histone |
Target entity | MACROH2A |
Product | # |
PMID for information on target | PMID:15897469 |
Comment | E3 ubiquitin ligase consisting of SPOP and CULLIN3=CUL3 is able to ubiquitinate the Polycomb group protein BMI1 and the variant histone MACROH2A. |
Status of entry | # |
Expression range: | 5.67 to 203.12 |
Mean expression: | 39.75 ± 22.54 |
Median expression: | 35.59 |