HGNC approved symbol | CUL4B |
HGNC ID | HGNC:2555 |
HGNC approved name | cullin 4B |
Entrez gene ID | GeneID:8450 (SSTAR profile) |
UniProt AC (human) | Q13620 |
UniProt ID (human) | CUL4B_HUMAN |
Pfam domains | Cullin PF00888 (214-814) Cullin_Nedd8 PF10557 (844-905) |
MGI symbol | Cul4b |
MGI ID | MGI:1919834 |
UniProt AC (mouse) | A2A432 |
UniProt ID (mouse) | CUL4B_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone ubiquitination |
PMID for information on function | PMID:16678110 |
Protein complex | # |
Target molecule | histone |
Target entity | H3, H4 |
Product | # |
PMID for information on target | PMID:16678110 |
Comment | Results shown in Figure 4A demonstrate that knockdown of CUL4A or CUL4B significantly reduces H3 and H4 ubiquitylation levels, indicating that both CUL4A and CUL4B contribute to histone H3 and H4 ubiquitylation in vivo. |
Status of entry | # |
Expression range: | 4.16 to 1109.25 |
Mean expression: | 61.81 ± 66.03 |
Median expression: | 45.0 |