HGNC approved symbol | CUL5 |
HGNC ID | HGNC:2556 |
HGNC approved name | cullin 5 |
Entrez gene ID | GeneID:8065 (SSTAR profile) |
UniProt AC (human) | Q93034 |
UniProt ID (human) | CUL5_HUMAN |
Pfam domains | Cullin PF00888 (18-671) Cullin_Nedd8 PF10557 (711-772) |
MGI symbol | Cul5 |
MGI ID | MGI:1922967 |
UniProt AC (mouse) | Q9D5V5 |
UniProt ID (mouse) | CUL5_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | DNA modification cofactor |
Modification | DNA methylation |
PMID for information on function | PMID:20847044 |
Protein complex | # |
Target molecule | DNA |
Target entity | # |
Product | # |
PMID for information on target | PMID:20847044 |
Comment | In cancer cells, many promoters become aberrantly methylated through the activity of the de novo DNA methyltransferases DNMT3a and DNMT3b and acquire repressive chromatin marks, and, indeed, DNMT3b interacted with CUL1, CUL2, CUL3, CUL4A, and CUL5. |
Status of entry | # |
Expression range: | 0.0 to 127.11 |
Mean expression: | 23.39 ± 11.48 |
Median expression: | 22.45 |