| HGNC approved symbol | ENY2 |
| HGNC ID | HGNC:24449 |
| HGNC approved name | enhancer of yellow 2 homolog (Drosophila) |
| Entrez gene ID | GeneID:56943
(SSTAR profile) |
| UniProt AC (human) | Q9NPA8 |
| UniProt ID (human) | ENY2_HUMAN |
| Pfam domains | EnY2 PF10163 (13-95) |
| MGI symbol | Eny2 |
| MGI ID | MGI:1919286 |
| UniProt AC (mouse) | Q9JIX0 |
| UniProt ID (mouse) | ENY2_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification erase cofactor |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:18206972 |
| Protein complex | SAGA |
| Target molecule | histone |
| Target entity | # |
| Product | # |
| PMID for information on target | PMID:18206972 |
| Comment | ATXN7L3, USP22, and ENY2 are required as cofactors for the full transcriptional activity by nuclear receptors. Thus, the deubiquitinase activity of the TFTC/STAGA HAT complex is necessary to counteract heterochromatin silencing and acts as a positive cofactor for activation by nuclear receptors in vivo. |
| Status of entry | # |