HGNC approved symbol | EYA1 |
HGNC ID | HGNC:3519 |
HGNC approved name | EYA transcriptional coactivator and phosphatase 1 |
Entrez gene ID | GeneID:2138 (SSTAR profile) |
UniProt AC (human) | Q99502 |
UniProt ID (human) | EYA1_HUMAN |
Pfam domains | Hydrolase PF00702 (323-566) |
MGI symbol | Eya1 |
MGI ID | MGI:109344 |
UniProt AC (mouse) | P97767 |
UniProt ID (mouse) | EYA1_MOUSE |
HGNC gene family tag | PTPE |
HGNC gene family description | Protein tyrosine phosphatases / Asp-based PTPs |
Function | Histone modification erase |
Modification | Histone phosphorylation |
PMID for information on function | PMID:19234442 |
Protein complex | # |
Target molecule | histone |
Target entity | H2AXT142 |
Product | # |
PMID for information on target | PMID:19234442 |
Comment | Eya effectively removes the phosphotyrosine mark from H2AX, while the phosphatase-inactive mutant Eya proteins (Eya1 D323A or Eya3 D246A) have little or no effect. |
Status of entry | # |