| HGNC approved symbol | FBL |
| HGNC ID | HGNC:3599 |
| HGNC approved name | fibrillarin |
| Entrez gene ID | GeneID:2091
(SSTAR profile) |
| UniProt AC (human) | P22087 |
| UniProt ID (human) | FBRL_HUMAN |
| Pfam domains | Fibrillarin PF01269 (88-314) |
| MGI symbol | Fbl |
| MGI ID | MGI:95486 |
| UniProt AC (mouse) | P35550 |
| UniProt ID (mouse) | FBRL_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:24352239 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2AQ104 |
| Product | H2AQ104me |
| PMID for information on target | PMID:24352239 |
| Comment | Nop1 is a methyltransferase in yeast, and fibrillarin is the orthologue enzyme in human cells. The modification is exclusively enriched over the 35S ribosomal DNA transcriptional unit. Glutamine methylation of H2A is the first histone epigenetic mark dedicated to a specific RNA polymerase and define its function as a regulator of FACT interaction with nucleosomes. |
| Status of entry | # |