HGNC approved symbol | HAT1 |
HGNC ID | HGNC:4821 |
HGNC approved name | histone acetyltransferase 1 |
Entrez gene ID | GeneID:8520 (SSTAR profile) |
UniProt AC (human) | O14929 |
UniProt ID (human) | HAT1_HUMAN |
Pfam domains | Hat1_N PF10394 (26-187) HAT1_C PF21183 (287-337) |
MGI symbol | Hat1 |
MGI ID | MGI:96013 |
UniProt AC (mouse) | Q8BY71 |
UniProt ID (mouse) | HAT1_MOUSE |
HGNC gene family tag | KAT |
HGNC gene family description | Chromatin-modifying enzymes / K-acetyltransferases |
Function | Histone modification write |
Modification | Histone acetylation |
PMID for information on function | PMID:9427644 |
Protein complex | # |
Target molecule | histone |
Target entity | H4, H2A |
Product | # |
PMID for information on target | PMID:9427644 |
Comment | The human holoenzyme consists of two subunits: a catalytic subunit, Hat1, and a subunit that binds core histones, p46, which greatly stimulates the acetyltransferase activity of Hat1. On the other hand, given that the Hat1 holoenzyme bound weakly to H2A and also acetylated the H2A |
Status of entry | # |
Expression range: | 1.44 to 231.32 |
Mean expression: | 43.34 ± 27.92 |
Median expression: | 37.58 |