HGNC approved symbol | HCFC2 |
HGNC ID | HGNC:24972 |
HGNC approved name | host cell factor C2 |
Entrez gene ID | GeneID:29915 (SSTAR profile) |
UniProt AC (human) | Q9Y5Z7 |
UniProt ID (human) | HCFC2_HUMAN |
Pfam domains | Kelch_1 PF01344 (22-60) Kelch_5 PF13854 (69-104, 312-354) Kelch_3 PF13415 (207-253) |
MGI symbol | Hcfc2 |
MGI ID | MGI:1915183 |
UniProt AC (mouse) | Q9D968 |
UniProt ID (mouse) | HCFC2_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write cofactor, Histone modification write cofactor |
Modification | Histone methylation, Histone acetylation |
PMID for information on function | PMID:15199122 |
Protein complex | MLL-HCF, CHD8, MLL2/3, MLL4/WBP7 |
Target molecule | histone |
Target entity | H3 |
Product | # |
PMID for information on target | PMID:15199122 |
Comment | HCF-2 (HCFC2), which specifically interact with a conserved binding motif in the MLL(N) (p300) subunit of MLL (histone methyltransferase ) and provide a potential mechanism for regulating its antagonistic transcriptional properties. |
Status of entry | # |
Expression range: | 0.0 to 21.94 |
Mean expression: | 3.39 ± 2.84 |
Median expression: | 2.62 |