| HGNC approved symbol | HDAC7 |
| HGNC ID | HGNC:14067 |
| HGNC approved name | histone deacetylase 7 |
| Entrez gene ID | GeneID:51564
(SSTAR profile) |
| UniProt AC (human) | Q8WUI4 |
| UniProt ID (human) | HDAC7_HUMAN |
| Pfam domains | Hist_deacetyl PF00850 (541-858) |
| MGI symbol | Hdac7 |
| MGI ID | MGI:1891835 |
| UniProt AC (mouse) | Q8C2B3 |
| UniProt ID (mouse) | HDAC7_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification erase |
| Modification | Histone acetylation |
| PMID for information on function | PMID:18285338 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2AKac, H2BKac, H3Kac, H4Kac |
| Product | H2AK, H2BK, H3K, H4K |
| PMID for information on target | PMID:18285338 |
| Comment | The isolated and purified catalytic domain of the human class IIa HDAC, cdHDAC7, has an intrinsic low level of deacetylase activity in the absence of any complex partner which can be inhibited by known HDAC inhibitors such as the hydroxamic acid TSA. It has been showen that the isolated catalytic domain of class IIa HDACs have weak but measurable intrinsic catalytic activity on chemically acetylated core histones. |
| Status of entry | # |