HGNC approved symbol | KDM1A |
HGNC ID | HGNC:29079 |
HGNC approved name | lysine (K)-specific demethylase 1A |
Entrez gene ID | GeneID:23028 (SSTAR profile) |
UniProt AC (human) | O60341 |
UniProt ID (human) | KDM1A_HUMAN |
Pfam domains | SWIRM PF04433 (183-264) Amino_oxidase PF01593 (288-826) |
MGI symbol | Kdm1a |
MGI ID | MGI:1196256 |
UniProt AC (mouse) | Q6ZQ88 |
UniProt ID (mouse) | KDM1A_MOUSE |
HGNC gene family tag | KDM |
HGNC gene family description | Chromatin-modifying enzymes / K-demethylases |
Function | Histone modification erase |
Modification | Histone methylation |
PMID for information on function | PMID:16223729 |
Protein complex | NuRD, BHC, SCL |
Target molecule | histone |
Target entity | H3K4me1, H3K4me2, H3K9me |
Product | H3K4, H3K9 |
PMID for information on target | PMID:16223729 |
Comment | Human histone demethylase LSD1=KDM1A is a flavin-dependent amine oxidase that catalyzes the specific removal of methyl groups from mono- and dimethylated Lys4 of histone H3. |
Status of entry | # |
Expression range: | 0.0 to 305.93 |
Mean expression: | 61.66 ± 38.01 |
Median expression: | 51.34 |