| HGNC approved symbol | KDM4A |
| HGNC ID | HGNC:22978 |
| HGNC approved name | lysine (K)-specific demethylase 4A |
| Entrez gene ID | GeneID:9682 (SSTAR profile) |
| UniProt AC (human) | O75164 |
| UniProt ID (human) | KDM4A_HUMAN |
| Pfam domains | JmjN PF02375 (14-49) JmjC PF02373 (175-291) PHD_2 PF13831 (732-767) zf-HC5HC2H_2 PF13832 (774-884) Tudor_2 PF18104 (902-936, 959-994) |
| MGI symbol | Kdm4a |
| MGI ID | MGI:2446210 |
| UniProt AC (mouse) | Q8BW72 |
| UniProt ID (mouse) | KDM4A_MOUSE |
| HGNC gene family tag | KDM, TDRD |
| HGNC gene family description | Chromatin-modifying enzymes / K-demethylases, Tudor domain containing |
| Function | Histone modification erase |
| Modification | Histone methylation |
| PMID for information on function | PMID:16603238 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K4me3, H3K36me3 |
| Product | H3K4me2, H3K36me2 |
| PMID for information on target | PMID:16603238 |
| Comment | The JmjC domain-containing protein JMJD2A =KDM4A reverses trimethylated H3-K9/K36 to di- but not mono- or unmethylated products. Overexpression of JMJD2A (but not a catalytically inactive mutant) reduces H3-K9/K36 trimethylation levels in cultured cells. |
| Status of entry | # |
| Expression range: | 4.22 to 115.19 |
| Mean expression: | 21.76 ± 9.52 |
| Median expression: | 20.22 |