HGNC approved symbol | MDC1 |
HGNC ID | HGNC:21163 |
HGNC approved name | mediator of DNA-damage checkpoint 1 |
Entrez gene ID | GeneID:9656 (SSTAR profile) |
UniProt AC (human) | Q14676 |
UniProt ID (human) | MDC1_HUMAN |
Pfam domains | FHA PF00498 (54-122) RTT107_BRCT_5 PF16770 (1888-1970) BRCT_2 PF16589 (1994-2074) |
MGI symbol | Mdc1 |
MGI ID | MGI:3525201 |
UniProt AC (mouse) | Q5PSV9 |
UniProt ID (mouse) | MDC1_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification read |
Modification | # |
PMID for information on function | PMID:16377563 |
Protein complex | # |
Target molecule | histone |
Target entity | H2AX |
Product | # |
PMID for information on target | PMID:16377563 |
Comment | Mammalian MDC1/NFBD1 directly binds to phospho-H2AX (gammaH2AX) by specifically interacting with the phosphoepitope at the gammaH2AX carboxyl terminus. |
Status of entry | # |
Expression range: | 0.0 to 65.65 |
Mean expression: | 11.34 ± 7.23 |
Median expression: | 10.09 |