HGNC approved symbol | MLLT6 |
HGNC ID | HGNC:7138 |
HGNC approved name | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 |
Entrez gene ID | GeneID:4302 (SSTAR profile) |
UniProt AC (human) | P55198 |
UniProt ID (human) | AF17_HUMAN |
Pfam domains | PHD_2 PF13831 (20-55) zf-HC5HC2H_2 PF13832 (63-180) |
MGI symbol | Mllt6 |
MGI ID | MGI:1935145 |
UniProt AC (mouse) | # |
UniProt ID (mouse) | # |
HGNC gene family tag | PHF |
HGNC gene family description | Zinc fingers, PHD-type |
Function | Histone modification write cofactor |
Modification | Histone methylation |
PMID for information on function | PMID:20203130 |
Protein complex | # |
Target molecule | histone |
Target entity | H3K79 |
Product | H3K79me3 |
PMID for information on target | PMID:20203130 |
Comment | MLLT6 =AF17, nucleosomes containing monoubiquitinated H2B are a better substrate for DotCom in the generation of trimethylated H3K79. DotCom requires monoubiquitination of H2B for H3K79 trimethylation. |
Status of entry | # |
Expression range: | 1.48 to 188.99 |
Mean expression: | 22.92 ± 20.17 |
Median expression: | 16.34 |