HGNC approved symbol | PADI3 |
HGNC ID | HGNC:18337 |
HGNC approved name | peptidyl arginine deiminase, type III |
Entrez gene ID | GeneID:51702 (SSTAR profile) |
UniProt AC (human) | Q9ULW8 |
UniProt ID (human) | PADI3_HUMAN |
Pfam domains | PAD_N PF08526 (1-113) PAD_M PF08527 (115-281) PAD PF03068 (290-661) |
MGI symbol | Padi3 |
MGI ID | MGI:1338891 |
UniProt AC (mouse) | Q9Z184 |
UniProt ID (mouse) | PADI3_MOUSE |
HGNC gene family tag | PADI |
HGNC gene family description | Peptidyl arginine deiminases |
Function | Histone modification |
Modification | Histone citrullination |
PMID for information on function | PMID:15087120 |
Protein complex | # |
Target molecule | histone |
Target entity | H2AR, H3R, H4R |
Product | H2ARci, H3Rci, H4Rci |
PMID for information on target | PMID:15087120 |
Comment | Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrullines. They are suspected to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis and possibly in regulation of gene expression through histone modification |
Status of entry | # |
Expression range: | 0.0 to 99.33 |
Mean expression: | 0.87 ± 5.93 |
Median expression: | 0.0 |