| HGNC approved symbol | PAK2 |
| HGNC ID | HGNC:8591 |
| HGNC approved name | p21 protein (Cdc42/Rac)-activated kinase 2 |
| Entrez gene ID | GeneID:5062 (SSTAR profile) |
| UniProt AC (human) | Q13177 |
| UniProt ID (human) | PAK2_HUMAN |
| Pfam domains | PBD PF00786 (73-130) Pkinase PF00069 (249-500) |
| MGI symbol | Pak2 |
| MGI ID | MGI:1339984 |
| UniProt AC (mouse) | Q8CIN4 |
| UniProt ID (mouse) | PAK2_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write |
| Modification | Histone phosphorylation |
| PMID for information on function | PMID:21724829 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H4S47 |
| Product | H4S47ph |
| PMID for information on target | PMID:21724829 |
| Comment | Phosphorylation of histone H4 Ser 47 (H4S47ph), catalyzed by the PAK2 kinase, promotes nucleosome assembly of H3.3-H4 and inhibits nucleosome assembly of H3.1-H4 by increasing the binding affinity of HIRA to H3.3-H4 and reducing association of CAF-1 with H3.1-H4. |
| Status of entry | # |
| Expression range: | 14.79 to 483.21 |
| Mean expression: | 73.58 ± 39.54 |
| Median expression: | 64.77 |