| HGNC approved symbol | PDP1 |
| HGNC ID | HGNC:9279 |
| HGNC approved name | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
| Entrez gene ID | GeneID:54704
(SSTAR profile) |
| UniProt AC (human) | Q9P0J1 |
| UniProt ID (human) | PDP1_HUMAN |
| Pfam domains | PP2C PF00481 (202-439) |
| MGI symbol | Pdp1 |
| MGI ID | MGI:2685870 |
| UniProt AC (mouse) | Q3UV70 |
| UniProt ID (mouse) | PDP1_MOUSE |
| HGNC gene family tag | PPM |
| HGNC gene family description | Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent |
| Function | Histone modification read |
| Modification | # |
| PMID for information on function | PMID:22150589 |
| Protein complex | # |
| Target molecule | histone, DNA |
| Target entity | H4K20me3 |
| Product | # |
| PMID for information on target | PMID:22150589 |
| Comment | The PWWP domain of Pdp1 binds not only to H4K20me3 (trimethylated Lys(20) of histone H4), but also to dsDNA (double-stranded DNA) via an aromatic cage and a positively charged area respectively. Pdp1 is a PWWP (proline-tryptophan-tryptophan-proline) domain-containing protein, which associates with Set9 to regulate its chromatin localization and methyltransferase activity towards H4K20. |
| Status of entry | # |