| HGNC approved symbol | PELP1 |
| HGNC ID | HGNC:30134 |
| HGNC approved name | proline, glutamate and leucine rich protein 1 |
| Entrez gene ID | GeneID:27043
(SSTAR profile) |
| UniProt AC (human) | Q8IZL8 |
| UniProt ID (human) | PELP1_HUMAN |
| Pfam domains | RIX1 PF08167 (75-231)
PELP1_HEAT PF08166 (425-473, 558-635) |
| MGI symbol | Pelp1 |
| MGI ID | MGI:1922523 |
| UniProt AC (mouse) | Q9DBD5 |
| UniProt ID (mouse) | PELP1_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification read, Histone modification write cofactor |
| Modification | Histone methylation, Histone acetylation |
| PMID for information on function | PMID:15456770, PMID:11481323 |
| Protein complex | CHD8, MLL2/3, MLL4/WBP7 |
| Target molecule | histone |
| Target entity | H1, H3, H4 |
| Product | # |
| PMID for information on target | PMID:15456770, PMID:15374949 |
| Comment | C-terminal glutamic acid-abundant region bound to the hypoacetylated histones H3 and H4 and prevents them from becoming substrates of histone acetyltransferase. Thus PELP1 promotes and maintains the hypoacetylated state of histones at the target genomic site, and ER binding reverses its role to hyperacetylate histones through an as yet unidentified mechanism. |
| Status of entry | # |