HGNC approved symbol | PIWIL4 |
HGNC ID | HGNC:18444 |
HGNC approved name | piwi-like RNA-mediated gene silencing 4 |
Entrez gene ID | GeneID:143689 (SSTAR profile) |
UniProt AC (human) | Q7Z3Z4 |
UniProt ID (human) | PIWL4_HUMAN |
Pfam domains | PAZ PF02170 (272-405) Piwi PF02171 (546-837) |
MGI symbol | Piwil4 |
MGI ID | MGI:3041167 |
UniProt AC (mouse) | Q8CGT6 |
UniProt ID (mouse) | PIWL4_MOUSE |
HGNC gene family tag | AGO |
HGNC gene family description | Argonaute/PIWI family |
Function | Chromatin remodeling, Histone modification erase cofactor |
Modification | Histone methylation |
PMID for information on function | PMID:17544373 |
Protein complex | # |
Target molecule | histone |
Target entity | H3K9 |
Product | # |
PMID for information on target | PMID:17544373 |
Comment | Induced histone H3 lysine 9 methylation at the p16(Ink4a) (CDKN2A) locus. Suggests that PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells. |
Status of entry | # |
Expression range: | 0.0 to 6.06 |
Mean expression: | 0.03 ± 0.38 |
Median expression: | 0.0 |