HGNC approved symbol | PKM |
HGNC ID | HGNC:9021 |
HGNC approved name | pyruvate kinase, muscle |
Entrez gene ID | GeneID:5315 (SSTAR profile) |
UniProt AC (human) | P14618 |
UniProt ID (human) | KPYM_HUMAN |
Pfam domains | PK PF00224 (43-375) PK_C PF02887 (411-528) |
MGI symbol | Pkm |
MGI ID | MGI:97591 |
UniProt AC (mouse) | P52480 |
UniProt ID (mouse) | KPYM_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write cofactor |
Modification | Histone phosphorylation |
PMID for information on function | PMID:24706538 |
Protein complex | # |
Target molecule | histone |
Target entity | H3S10, H3S28, H2BS32 |
Product | H3S10ph, H3S28ph, H2BS32ph, H3T11ph |
PMID for information on target | PMID:24706538 |
Comment | Transcriptional activation by epidermal growth factor (EGF) is mediated via phosphorylation of H3S10, H3S28, and H2BS32 by Rsk-2 and PKM2. |
Status of entry | # |
Expression range: | 13.94 to 6979.25 |
Mean expression: | 1591.68 ± 1299.19 |
Median expression: | 1322.4 |