HGNC approved symbol | PRKAA1 |
HGNC ID | HGNC:9376 |
HGNC approved name | protein kinase, AMP-activated, alpha 1 catalytic subunit |
Entrez gene ID | GeneID:5562 (SSTAR profile) |
UniProt AC (human) | Q13131 |
UniProt ID (human) | AAPK1_HUMAN |
Pfam domains | Pkinase PF00069 (27-279) AMPK_alpha_AID PF21147 (299-343) AdenylateSensor PF16579 (406-479) |
MGI symbol | Prkaa1 |
MGI ID | MGI:2145955 |
UniProt AC (mouse) | Q5EG47 |
UniProt ID (mouse) | AAPK1_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification write |
Modification | Histone phosphorylation |
PMID for information on function | PMID:20647423 |
Protein complex | # |
Target molecule | histone |
Target entity | H2BS36 |
Product | H2BS36ph |
PMID for information on target | # |
Comment | In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Part of AMPK. |
Status of entry | # |
Expression range: | 1.57 to 157.16 |
Mean expression: | 37.93 ± 19.31 |
Median expression: | 35.3 |