| HGNC approved symbol | PRKDC |
| HGNC ID | HGNC:9413 |
| HGNC approved name | protein kinase, DNA-activated, catalytic polypeptide |
| Entrez gene ID | GeneID:5591 (SSTAR profile) |
| UniProt AC (human) | P78527 |
| UniProt ID (human) | PRKDC_HUMAN |
| Pfam domains | DNA-PKcs_N PF20500 (15-874) DNAPKcs_CC1-2 PF20502 (1001-1796) DNAPKcs_CC3 PF08163 (1596-1947, 1825-2207) DNAPKcs_CC5 PF19704 (2131-2890) FAT PF02259 (2943-3468) PI3_PI4_kinase PF00454 (3749-4013) FATC PF02260 (4098-4128) |
| MGI symbol | Prkdc |
| MGI ID | MGI:104779 |
| UniProt AC (mouse) | P97313 |
| UniProt ID (mouse) | PRKDC_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write |
| Modification | Histone phosphorylation |
| PMID for information on function | PMID:14627815 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2AXS139, H2AFXS139 |
| Product | H2AXS139ph, H2AFXS139ph |
| PMID for information on target | PMID:14627815 |
| Comment | Acetylation largely enhances the phosphorylation of H2AX by DNA-PK=PRKDC, and this acetylation effect is observed when H2AX exists in the context of nucleosomes but not in a free form. |
| Status of entry | # |
| Expression range: | 4.18 to 461.44 |
| Mean expression: | 84.97 ± 61.5 |
| Median expression: | 66.11 |