| HGNC approved symbol | RBBP4 |
| HGNC ID | HGNC:9887 |
| HGNC approved name | retinoblastoma binding protein 4 |
| Entrez gene ID | GeneID:5928 (SSTAR profile) |
| UniProt AC (human) | Q09028 |
| UniProt ID (human) | RBBP4_HUMAN |
| Pfam domains | CAF1C_H4-bd PF12265 (19-88) WD40 PF00400 (173-206, 221-256, 265-302, 309-346, 367-402) |
| MGI symbol | Rbbp4 |
| MGI ID | MGI:1194912 |
| UniProt AC (mouse) | Q60972 |
| UniProt ID (mouse) | RBBP4_MOUSE |
| HGNC gene family tag | WDR |
| HGNC gene family description | WD repeat domain containing |
| Function | Histone chaperone |
| Modification | # |
| PMID for information on function | PMID:8858152 |
| Protein complex | NuRF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, NuRD, mSin3A, core HDAC, mSin3A-like complex, PRC2, CAF-1 |
| Target molecule | histone |
| Target entity | H4 |
| Product | # |
| PMID for information on target | PMID:8858152 |
| Comment | RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and RBBP4, respectively) are highly homologous histone chaperones that play key roles in establishing and maintaining chromatin structure. Human p48 =RBBP4 can bind to histone H4 in the absence of CAF-1 p150 and p60. p48, also a known subunit of a histone deacetylase, copurifies with a chromatin assembly complex (CAC), which contains the three subunits of CAF-1 (p150, p60, p48) and H3 and H4, and promotes DNA replication-dependent chromatin assembly. |
| Status of entry | # |
| Expression range: | 23.34 to 314.19 |
| Mean expression: | 86.7 ± 41.88 |
| Median expression: | 75.26 |