| HGNC approved symbol | RBX1 |
| HGNC ID | HGNC:9928 |
| HGNC approved name | ring-box 1, E3 ubiquitin protein ligase |
| Entrez gene ID | GeneID:9978
(SSTAR profile) |
| UniProt AC (human) | P62877 |
| UniProt ID (human) | RBX1_HUMAN |
| Pfam domains | zf-rbx1 PF12678 (40-98) |
| MGI symbol | Rbx1 |
| MGI ID | MGI:1891829 |
| UniProt AC (mouse) | P62878 |
| UniProt ID (mouse) | RBX1_MOUSE |
| HGNC gene family tag | RNF |
| HGNC gene family description | RING-type (C3HC4) zinc fingers |
| Function | Histone modification write cofactor |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:18593899 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3, H4 |
| Product | H3ub, H4ub |
| PMID for information on target | PMID:18593899 |
| Comment | Histones H3 and H4 are targets of the CUL4-DDB-RBX1 E3 ligase ( 34). It has been proposed that both DDB1-CUL4DDB2 and Ring2 ligases are recruited to UV-induced lesions to modify histones. |
| Status of entry | # |