HGNC approved symbol | SAP25 |
HGNC ID | HGNC:41908 |
HGNC approved name | Sin3A-associated protein, 25kDa |
Entrez gene ID | GeneID:100316904 (SSTAR profile) |
UniProt AC (human) | Q8TEE9 |
UniProt ID (human) | SAP25_HUMAN |
Pfam domains | SAP25 PF15476 (17-193) |
MGI symbol | Sap25 |
MGI ID | MGI:3802945 |
UniProt AC (mouse) | Q1EHW4 |
UniProt ID (mouse) | SAP25_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification erase cofactor |
Modification | Histone acetylation |
PMID for information on function | PMID:16449650 |
Protein complex | # |
Target molecule | histone |
Target entity | # |
Product | # |
PMID for information on target | PMID:16449650 |
Comment | SAP25 binds to the PAH1 domain of mSin3A, associates with the mSin3A-HDAC complex in vivo, and represses transcription when tethered to DNA. SAP25 is required for mSin3A-mediated, but not N-CoR-mediated, repression. |
Status of entry | # |