| HGNC approved symbol | SETDB1 |
| HGNC ID | HGNC:10761 |
| HGNC approved name | SET domain, bifurcated 1 |
| Entrez gene ID | GeneID:9869 (SSTAR profile) |
| UniProt AC (human) | Q15047 |
| UniProt ID (human) | SETB1_HUMAN |
| Pfam domains | DUF5604 PF18300 (193-250) Tudor_5 PF18359 (258-311) Tudor_4 PF18358 (348-398) MBD PF01429 (596-667) Pre-SET PF05033 (683-798) SET PF00856 (1199-1266) |
| MGI symbol | Setdb1 |
| MGI ID | MGI:1934229 |
| UniProt AC (mouse) | O88974 |
| UniProt ID (mouse) | SETB1_MOUSE |
| HGNC gene family tag | KMT, TDRD |
| HGNC gene family description | Chromatin-modifying enzymes / K-methyltransferases, Tudor domain containing |
| Function | Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:11959841 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K9 |
| Product | H3K9me3 |
| PMID for information on target | PMID:11959841 |
| Comment | In vitro methylation of the N-terminal tail of histone H3 by SETDB1 is sufficient to enhance the binding of HP1 proteins, which requires both an intact chromodomain and chromoshadow domain. |
| Status of entry | # |
| Expression range: | 1.66 to 69.3 |
| Mean expression: | 17.54 ± 8.95 |
| Median expression: | 15.37 |