| HGNC approved symbol | SETMAR |
| HGNC ID | HGNC:10762 |
| HGNC approved name | SET domain and mariner transposase fusion gene |
| Entrez gene ID | GeneID:6419 (SSTAR profile) |
| UniProt AC (human) | Q53H47 |
| UniProt ID (human) | SETMR_HUMAN |
| Pfam domains | Pre-SET PF05033 (28-132) SET PF00856 (148-263) HTH_48 PF17906 (346-392) Transposase_1 PF01359 (502-581) |
| MGI symbol | Setmar |
| MGI ID | MGI:1921979 |
| UniProt AC (mouse) | Q80UJ9 |
| UniProt ID (mouse) | SETMR_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:16332963 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K4, H3K36 |
| Product | H3K4me, H3K36me |
| PMID for information on target | PMID:16332963 |
| Comment | Metnase =SETMAR that has a SET domain and a transposase/nuclease domain. Metnase methylates histone H3 lysines 4 and 36, which are associated with open chromatin. Metnase increases resistance to ionizing radiation and increases nonhomologous end-joining repair of DNA doublestrand breaks. |
| Status of entry | # |
| Expression range: | 0.0 to 32.58 |
| Mean expression: | 7.21 ± 4.77 |
| Median expression: | 6.01 |