HGNC approved symbol | SF3B1 |
HGNC ID | HGNC:10768 |
HGNC approved name | splicing factor 3b, subunit 1, 155kDa |
Entrez gene ID | GeneID:23451 (SSTAR profile) |
UniProt AC (human) | O75533 |
UniProt ID (human) | SF3B1_HUMAN |
Pfam domains | SF3b1 PF08920 (327-453) domain PF22646 (1086-1158) |
MGI symbol | Sf3b1 |
MGI ID | MGI:1932339 |
UniProt AC (mouse) | Q99NB9 |
UniProt ID (mouse) | SF3B1_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | RNA modification |
Modification | # |
PMID for information on function | PMID:23568491 |
Protein complex | B-WICH |
Target molecule | RNA |
Target entity | # |
Product | # |
PMID for information on target | PMID:23568491 |
Comment | Although the causative link between SF3B1 mutation and CLL pathogenesis remains unclear, several lines of evidence suggest SF3B1 mutation might be linked to genomic stability and epigenetic modification. |
Status of entry | # |
Expression range: | 3.59 to 1017.34 |
Mean expression: | 150.23 ± 100.24 |
Median expression: | 128.47 |