| HGNC approved symbol | SFMBT2 |
| HGNC ID | HGNC:20256 |
| HGNC approved name | Scm-like with four mbt domains 2 |
| Entrez gene ID | GeneID:57713 (SSTAR profile) |
| UniProt AC (human) | Q5VUG0 |
| UniProt ID (human) | SMBT2_HUMAN |
| Pfam domains | MBT PF02820 (78-146, 191-258, 301-375, 411-478) SLED PF12140 (529-642) SAM_1 PF00536 (823-885) |
| MGI symbol | Sfmbt2 |
| MGI ID | MGI:2447794 |
| UniProt AC (mouse) | Q5DTW2 |
| UniProt ID (mouse) | SMBT2_MOUSE |
| HGNC gene family tag | SAMD |
| HGNC gene family description | Sterile alpha motif (SAM) domain containing |
| Function | Histone modification read, Polycomb group (PcG) protein, TF |
| Modification | TF repressor |
| PMID for information on function | PMID:23385818 |
| Protein complex | # |
| Target molecule | histone, DNA |
| Target entity | H3K9me2, H3K9me3, H3K27me3, H4K20me2, H4K20me3 |
| HOCOMOCO TFBS model | |
| Product | H3, H4 |
| PMID for information on target | PMID:23385818 |
| Comment | SFMBT2 binds preferentially to methylated histone H3 and H4 that are associated with transcriptional repression. Occupancy of SFMBT2 coincide with enrichment of diand tri-methylated H3K9 and H4K20 as well as tri-methylated H3K27 at the HOXB13 gene promoter. |
| Status of entry | # |
| Expression range: | 0.0 to 25.58 |
| Mean expression: | 0.27 ± 1.22 |
| Median expression: | 0.0 |