| HGNC approved symbol | SIRT1 |
| HGNC ID | HGNC:14929 |
| HGNC approved name | sirtuin 1 |
| Entrez gene ID | GeneID:23411
(SSTAR profile) |
| UniProt AC (human) | Q96EB6 |
| UniProt ID (human) | SIR1_HUMAN |
| Pfam domains | SIR2 PF02146 (261-447) |
| MGI symbol | Sirt1 |
| MGI ID | MGI:2135607 |
| UniProt AC (mouse) | Q923E4 |
| UniProt ID (mouse) | SIR1_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Histone modification erase, Histone modification write cofactor |
| Modification | Histone acetylation, Histone methylation |
| PMID for information on function | PMID:15469825 |
| Protein complex | eNoSc |
| Target molecule | histone |
| Target entity | H1K26ac, H3K9ac, H4K16ac |
| Product | H1K26, H3K9, H4K16 |
| PMID for information on target | PMID:15469825 |
| Comment | SirT1 deacetylates histone polypeptides with a preference for histone H4 lysine 16 (H4-K16Ac) and H3 lysine 9 (H3-K9Ac) in vitro. |
| Status of entry | # |