HGNC approved symbol | SIRT7 |
HGNC ID | HGNC:14935 |
HGNC approved name | sirtuin 7 |
Entrez gene ID | GeneID:51547 (SSTAR profile) |
UniProt AC (human) | Q9NRC8 |
UniProt ID (human) | SIR7_HUMAN |
Pfam domains | SIR2 PF02146 (140-273) |
MGI symbol | Sirt7 |
MGI ID | MGI:2385849 |
UniProt AC (mouse) | Q8BKJ9 |
UniProt ID (mouse) | SIR7_MOUSE |
HGNC gene family tag | # |
HGNC gene family description | # |
Function | Histone modification erase |
Modification | Histone acetylation |
PMID for information on function | PMID:22722849 |
Protein complex | B-WICH |
Target molecule | histone |
Target entity | H3K18ac |
Product | H3K18 |
PMID for information on target | PMID:22722849 |
Comment | Genome-wide binding studies reveal that SIRT7 binds to promoters of a specific set of gene targets, where it deacetylates H3K18Ac and promotes transcriptional repression. |
Status of entry | # |